Title
Patient reported outcomes and experience measures in clinical trials of critically ill adults with sepsis: A scoping review
Link to article in PubMed
Author(s)
Hibbert, Elizabeth
Leggett, Nina
Kim, Dasom
De Silva, Sheraya
Messiha, Rose
Abbenbroek, Brett
Deane, Adam
Dye, Jacob
Eastwood, Glenn
Finfer, Simon
Higgins, Alisa
Hodgson, Carol L
Hutcheon, Evelyn
Litton, Edward
O'Dowd, Mick
Pilcher, David
Poole, Alexis
Prescott, Hallie C
Saxena, Manoj
Shekar, Kiran
Valentine, Korina
Udy, Andrew
Haines, Kimberley J
Abstract
Sepsis survivors may experience ongoing health challenges after hospitalization for sepsis. Patient Reported Outcome Measures (PROMs) and Patient Reported Experience Measures (PREMs) are important endpoints to assess patient health status, and health system performance. This review aimed to: 1) identify and describe the PROMs and PREMs used in Randomised Controlled Trials (RCTs) of critically ill adults with sepsis; and 2) determine the 'survivor-centricity' of these measures. MEDLINE, Embase, CINAHL Plus and PsycINFO were searched on 18 November 2024. Studies were included if they were: 1) conducted in adult patients admitted to the Intensive Care Unit (ICU) with sepsis; 2) RCTs (or a follow-up study of an RCT); 3) included at least one PROM or PREM; 4) published since 1 January 2000, in English, and available in full text. 7667 studies were screened for eligibility. Eighteen studies were included (n = 21,439 patients). Nine (50%) studies were RCTs, and 9 (50%) were RCT follow-up studies. A total of 21 PROMs, and one PREM were identified in these 18 studies. The most common PROM was health-related quality of life (HRQoL), measured in 17 (94%) studies, via the EuroQol-5D-5L (n = 10, 56%). Most PROMs (n = 13, 62%) were aligned with the survivor-centricity health domain of psychological impairment. Only one study reported a PREM that captured the patient experience of chronic care. In RCTs of patients admitted to the ICU with sepsis, HRQoL was the most frequently measured PROM. Only one PREM was identified. HRQoL captured the most survivor-centricity domains.
Publication information
Ann Am Thorac Soc. 2026 Apr 16:aaoag102. doi: 10.1093/annalsats/aaoag102. Online ahead of print.
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Patient reported outcomes and experience measures.pdf
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Re-used under a Creative Commons Attribution License: https://creativecommons.org/licenses/by-nc/4.0/
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989.38 KB
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Adobe PDF
Checksum
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Date Issued
2026-04-16
Type
Journal Article
Journal Title
Annals of the American Thoracic Society
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