NT Health Research and Publications Online

Welcome to NT Health Research and Publications Online, an open access digital repository that showcases the research projects and output of researchers working for the Northern Territory Department of Health (NT Health), while also collecting and preserving publications and multimedia produced in an official capacity, that represent the department. This service is maintained by NT Health Library Services
All Publications
4275
Projects
61
People
370
Recent Additions
  • Person
  • Publication
    Journal Article
    Top End hospital leads the green revolution in health care
    (2024-06-03)
    A volunteer project at Royal Darwin Hospital (RDH) is using native landscapes to adapt to climate while enhancing wellbeing, Indigenous cultural security and local biodiversity.
  • Person
  • Publication
    Journal Article
    The characteristics of SARS-CoV-2-positive children in Australian hospitals: a PREDICT network study.
    (2023-06-05)
    Ibrahim, Laila
    ;
    Wilson, Catherine
    ;
    Tham, Doris
    ;
    Corden, Mark
    ;
    Jani, Shefali
    ;
    Zhang, Michael
    ;
    Kochar, Amit
    ;
    Tan, Ker Fern
    ;
    George, Shane
    ;
    Phillips, Natalie T
    ;
    Buntine, Paul
    ;
    Robins-Browne, Karen
    ;
    Chong, Vimuthi
    ;
    Georgeson, Thomas
    ;
    ;
    Davidson, Sarah
    ;
    O'Brien, Sharon
    ;
    Tran, Viet
    ;
    Babl, Franz E
    To examine the clinical characteristics and short term outcomes for children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who presented to Australian hospitals during 2020 and 2021.Retrospective case review study in nineteen hospitals of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network from all Australian states and territories, including seven major paediatric tertiary centres and eight Victorian hospitals.SARS-CoV-2-positive people under 18 years of age who attended emergency departments or were admitted to hospital during 1 February 2020 - 31 December 2021.Epidemiological and clinical characteristics, by hospital care type (emergency department [ED] or inpatient care).A total of 1193 SARS-CoV-2-positive children and adolescents (527 girls, 44%) attended the participating hospitals (107 in 2020, 1086 in 2021). Their median age was 3.8 years (interquartile range [IQR], 0.8-11.4 years); 63 were Aboriginal or Torres Strait Islander people (5%). Other medical conditions were recorded for 293 children (25%), including asthma (86, 7%) and premature birth (68, 6%). Medical interventions were not required during 795 of 1181 ED presentations (67%); children were discharged directly home in 764 cases (65%) and admitted to hospital in 282 (24%; sixteen to intensive care units). The 384 admissions to hospital (including 102 direct admissions) of 341 children (25 infants under one month of age) included 23 to intensive care (6%); the median length of stay was three days (IQR, 1-9 days). Medical interventions were not required during 261 admissions (68%); 44 children received respiratory support (11%) and 21 COVID-19-specific treatments, including antiviral and biologic agents (5%). Being under three months of age (v one year to less than six years: odds ratio [OR], 2.6; 95% confidence interval [CI], 1.7-4.0) and pre-existing medical conditions (OR, 2.5; 95% CI, 1.9-3.2) were the major predictors of hospital admission. Two children died, including one without a known pre-existing medical condition.During 2020 and 2021, most SARS-CoV-2-positive children and adolescents who presented to participating hospitals could be managed as outpatients. Outcomes were generally good, including for those admitted to hospital.
  • Publication
    Journal Article
    Sepsis associated acute kidney injury is common among Aboriginal and Torres Strait Islanders with septic shock and has poor outcomes: A nested cohort study.
    (2024-10-08)
    Donaldson, L H
    ;
    Hammond, N E
    ;
    Smyth, K L
    ;
    ;
    Taylor, Sean
    ;
    Bompoint, S
    ;
    Coombes, J
    ;
    Bennett-Brook, K
    ;
    Bellomo, R
    ;
    Myburgh, J
    ;
    Venkatesh, B
    Exploration of the incidence and outcomes of Acute Kidney Injury (AKI) broadly, and sepsis associated AKI specifically, in Aboriginal and Torres Strait Islander (First Nations) people has been limited. We compared a nested cohort of First Nations people drawn from a multinational randomised controlled trial of hydrocortisone in septic shock, to a cohort matched for age, sex and severity of illness. Acute Kidney Injury was defined using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, as well as incident use of kidney replacement therapy (KRT). Major Adverse Kidney Events (MAKE) were described as the composite of death, new dialysis requirement or persisting kidney dysfunction at hospital discharge. A cohort of 57 Aboriginal and/or Torres Strait Islander patients with septic shock was identified. 91.2% (52) of the First Nations cohort met KDIGO criteria for Stage 1 AKI or greater and 63% (36) met Stage 3 criteria. 59.6% (34) of the First Nations required dialysis as compared to 45.6% (26) in the matched cohort. 60.7% (34) of First Nations participants met criteria for MAKE at hospital discharge. The proportions requiring dialysis at 6, 12 and 24 months were 8.3%, 9.1% and 6.9% respectively. The incidences of AKI and MAKE reported in this First Nations cohort are substantially higher than in previously published cohorts of patients with sepsis, even those that use sensitive definitions of AKI. Measures to promote better management of infectious diseases in First Nations communities are required.
Most viewed