Prostatic abscess is a rare complication of acute bacterial prostatitis and is most commonly caused by
Enterobacteriaceae. We report on a case of prostatic abscess caused by Staphylococcus aureus and conduct a review of the literature. We present a case of S. aureus prostatic abscess that was successfully treated with a
combination of antibiotic and surgical therapy. The isolate was non–multidrug-resistant, methicillin-resistant
Staphylococcus aureus and was genotyped as clonal complex 5, an emerging regional clone that is trimethoprim resistant and Panton-Valentine leukocidin positive. This current case report is the first to describe the use of clindamycin step-down therapy. A literature review identified a further 39 cases of S. aureus prostatic abscesses, of which 26 were methicillin resistant. S. aureus is an uncommon cause of prostatic abscess. Optimal management includes both antibiotic
therapy and surgical drainage. Our use of clindamycin as step-down therapy was guided by its excellent prostatic penetration.