External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis.

Author(s)
Long, Elliot
Borland, Meredith L
George, Shane
Jani, Shefali
Tan, Eunicia
Phillips, Natalie
Kochar, Amit
Craig, Simon
Lithgow, Anna
Rao, Arjun
Dalziel, Stuart
Oakley, Ed
Hearps, Stephen
Gelbart, Ben
McNab, Sarah
Balamuth, Fran
Weiss, Scott L
Kuppermann, Nathan
Brad, Charlotte
Williams, Amanda
Babl, Franz E
Publication Date
2025-03-03
Abstract
The novel Phoenix Sepsis Score and sepsis criteria were derived and validated using a multicountry dataset and proposed as a new definition for sepsis in children.To externally validate the Phoenix Sepsis Score and sepsis criteria in a cohort of children hospitalized with suspected community-acquired sepsis.This diagnostic study used data from the multicenter, multicountry Sepsis Epidemiology in Australian and New Zealand Emergency Departments (SENTINEL) study, collected from 2021 to 2023 and including 90-day follow-up. Children admitted to the hospital through 11 emergency departments in Australia and New Zealand and treated with parenteral antibiotics with either (1) a provisional diagnosis of sepsis or (2) treatment for sepsis (intravenous fluid bolus to treat poor perfusion) were included.Development of organ dysfunction over the first 24 hours of hospitalization.The main outcomes were (1) in-hospital mortality and (2) death or requirement for extracorporeal life support (ECLS) within 72 hours of hospitalization.A total of 6232 children were included in the analysis, with a median (IQR) age of 2.1 (0.3-7.1) years, 3386 (54.1%) male, in-hospital mortality of 60 (1.0%), and death or ECLS within 72 hours in 36 (0.6%). In this population, the worst Phoenix Sepsis Score calculated over the first 24 hours of hospitalization had an area under the precision recall curve of 0.17 (95% CI, 0.07-0.28) for predicting in-hospital mortality and 0.23 (95% CI, 0.11-0.36) for predicting death or ECLS within 72 hours. Overall, 306 children (4.9%) met the Phoenix sepsis criteria, of whom 33 (10.8%) died in the hospital (nearly half of the total number who died) and 28 (9.2%) died or required ECLS within 72 hours. The Phoenix sepsis criteria had a sensitivity of 55.0% (95% CI, 41.6%-67.9%) and positive predictive value (PPV) of 10.8% (95% CI, 7.6%-14.9%) for in-hospital mortality and sensitivity of 77.8% (95% CI, 60.8%-89.9%) and PPV of 9.2% (95% CI, 6.2%-13.0%) for death or ECLS within 72 hours. Coagulation data for the calculation of the Phoenix Sepsis Score were missing in more than 85% of children.In this multicenter diagnostic study of children hospitalized with suspected sepsis, the Phoenix Sepsis Score and sepsis criteria had similar performance to the original derivation and validation cohorts. The small proportion of children meeting Phoenix sepsis criteria, missingness of data, timing of application, and lack of sensitivity for in-hospital mortality limit the clinical utility of the criteria.
Affiliation
Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Department of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Department of Emergency Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Divisions of Emergency Medicine and Paediatrics, School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
Department of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, Queensland, Australia.
School of Medicine and Dentistry, Griffith University, Southport, Queensland, Australia.
Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Department of Emergency Medicine, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Middlemore Hospital, Aukland, New Zealand.
Department of Surgery and Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.
Emergency Department, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Child Health Research Centre, University of Queensland, Queensland, Australia.
Department of Emergency Medicine, Women and Children's Hospital, Adelaide, South Australia, Australia.
Department of Acute Care Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Paediatric Emergency Department, Monash Medical Centre, Monash Health, Victoria, Australia.
Department of Paediatrics, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
Department of Paediatrics, Royal Darwin Hospital, Tiwi, Northern Territory, Australia.
Department of Emergency Medicine, Sydney Children's Hospital, Randwick, New South Wales, Australia.
School of Women's and Children's Health, University of New South Wales, Kensington, New South Wales, Australia.
Department of Surgery and Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.
Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.
Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Department of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Paediatric Intensive Care Unit, The Royal Children's Hospital, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Department of General Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia.
Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Nemours Children's Health and Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
Departments of Pediatrics and Emergency Medicine, the George Washington School of Medicine and Health Sciences, and Children's National Hospital, Washington, DC.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Department of Critical Care, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Citation
JAMA Netw Open . 2025 Mar 3;8(3):e251412. doi: 10.1001/jamanetworkopen.2025.1412.
ISSN
2574-3805
Pubmed ID
https://pubmed.ncbi.nlm.nih.gov/40116825/?otool=iaurydwlib
Link
MESH subject
Humans
Sepsis
Male
Female
Community-Acquired Infections
Child
Child, Preschool
Infant
New Zealand
Australia
Hospital Mortality
Severity of Illness Index
Title
External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis.
Type of document
Journal Article
Entity Type
Publication

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