Thompson, F

Russell, S

Quigley, R

Sagigi, B

Miller, G

Esterman, A

Harriss, L

Taylor, S

McDermott, R

Strivens, E

2023-06

BACKGROUND: Reducing the burden of dementia in First Nations populations may be addressed through developing population specific methods to quantify future risk of dementia. OBJECTIVE: To adapt existing dementia risk models to cross-sectional dementia prevalence data from a First Nations population in the Torres Strait region of Australia in preparation for follow-up of participants. To explore the diagnostic utility of these dementia risk models at detecting dementia. METHODS: A literature review to identify existing externally validated dementia risk models. Adapting these models to cross-sectional data and assessing their diagnostic utility through area under the receiver operating characteristic curve (AUROC) analyses and calibration using Hosmer-Lemeshow Chi(2). RESULTS: Seven risk models could be adapted to the study data. The Aging, Cognition and Dementia (AgeCoDe) study, the Framingham Heart Study (FHS), and the Brief Dementia Screening Indicator (BDSI) had moderate diagnostic utility in identifying dementia (i.e., AUROC >0.70) before and after points for older age were removed. CONCLUSION: Seven existing dementia risk models could be adapted to this First Nations population, and three had some cross-sectional diagnostic utility. These models were designed to predict dementia incidence, so their applicability to identify prevalent cases would be limited. The risk scores derived in this study may have prognostic utility as participants are followed up over time. In the interim, this study highlights considerations when transporting and developing dementia risk models for First Nations populations.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

University of South Australia, SA, Australia.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.

Queensland Health, Torres and Cape Hospital and Health Service, Thursday Island, QLD, Australia.

Top End Health Service, Northern Territory Government, Darwin, NT, Australia.

© 2023 – The authors. Published by IOS Press.

J Alzheimers Dis Rep. 2023 Jun 5;7(1):543-555. doi: 10.3233/ADR-220093. eCollection 2023.

https://pubmed.ncbi.nlm.nih.gov/37313487/?otool=iaurydwlib

https://hdl.handle.net/10137/12479

7

Dementia Risk Models in an Australian First Nations Population: Cross-Sectional Associations and Preparation for Follow-Up.

Journal Article

Publication