Bowen AC

Carapetis JR

Currie BJ

Fowler VG

Chambers HF

Tong SYC

2017

Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or Staphylococcus aureus, including methicillin-resistant (MRSA). We identified 196 studies, and 15 underwent full text review by 2 reviewers. Observational studies, which mainly focused on SSTI due to S aureus, supported the use of SXT when compared with clindamycin or β-lactams. Of 10 randomized controlled trials, 8 demonstrated the efficacy of SXT for SSTI treatment including conditions involving GAS. These findings support SXT use for treatment of impetigo and purulent cellulitis (without an additional β-lactam agent) and abscess and wound infection. For nonpurulent cellulitis, β-lactams remain the treatment of choice.

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth.. Princess Margaret Hospital for Children, Perth, Western Australia.. Menzies School of Health Research, Charles Darwin University, North Territory, Australia..

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth.. Princess Margaret Hospital for Children, Perth, Western Australia..

Menzies School of Health Research, Charles Darwin University, North Territory, Australia.. Royal Darwin Hospital, North Territory, Australia..

Duke University Division of Infectious Diseases, Durham, North Carolina..

Division of Infectious Disease, Department of Medicine, San Francisco General Hospital, California..

Menzies School of Health Research, Charles Darwin University, North Territory, Australia.. Victorian Infectious Disease Service, The Royal Melbourne Hospital, and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia..

Open forum infectious diseases 2017; 4(4): ofx232

2328-8957

https://pubmed.ncbi.nlm.nih.gov/29255730/?otool=iaurydwlib

https://hdl.handle.net/10137/5160

Staphylococcus aureus

group A Streptococcus (GAS)

impetigo

skin and soft tissue infections

sulfamethoxazole- trimethoprim

Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.

Journal Article

Review

Publication