Ketharanathan, Tharini; Hanwella, Raveen; Weerasundera, Rajiv; de Silva, Varuni Asanka

Author(s)

Ketharanathan, Tharini

Hanwella, Raveen

Weerasundera, Rajiv

de Silva, Varuni Asanka

Publication Date

2016-05

Abstract

The Montgomery-Asberg Depression Rating Scale (MADRS) is commonly used to assess major depression in Parkinson disease (PD), but studies on its utility are few. This study examines the validity and factor structure of MADRS in population with PD. In 104 patients with idiopathic PD, major depression was diagnosed by Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision; DSM-IV-TR) criteria, and all patients were rated by MADRS. The MADRS showed good concurrent validity with DSM-IV-TR criteria. The diagnostic cutoff was established as 16/17 (sensitivity 97.43, specificity 100%, positive predictive value 100%, and negative predictive value 98.48%). Factor analysis identified 3 factors, accounting for 76% of total variance: "sadness-anhedonia" comprising apparent sadness, reported sadness, concentration difficulties, lassitude, inability to feel, pessimistic thoughts, and suicidal ideas; "anxiety" with reduced sleep and inner tension; and "vegetative symptoms" with reduced appetite. The MADRS has diagnostic utility in major depression in PD. The 3-factor structure of MADRS may help to understand the different dimensions of major depression and identify distinct symptom subgroups in this population.

Citation

Journal of geriatric psychiatry and neurology 2016-05; 29(3): 115-9

ISSN

0891-9887

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/26392481/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5436

Subject

Parkinson disease

depression

geriatric psychiatry

mental health

MESH subject

Adult

Aged

Aged, 80 and over

Anhedonia

Anxiety

Anxiety Disorders

Depression

Depressive Disorder, Major

Diagnostic and Statistical Manual of Mental Disorders

Female

Humans

Male

Middle Aged

Parkinson Disease

Psychiatric Status Rating Scales

Reproducibility of Results

Sensitivity and Specificity

Factor Analysis, Statistical

Title

Diagnostic Validity and Factor Analysis of Montgomery-Asberg Depression Rating Scale in Parkinson Disease Population.

Type of document

Journal Article

Validation Study

Entity Type

Publication

Author(s)	Ketharanathan, Tharini Hanwella, Raveen Weerasundera, Rajiv de Silva, Varuni Asanka
Publication Date	2016-05
Abstract	The Montgomery-Asberg Depression Rating Scale (MADRS) is commonly used to assess major depression in Parkinson disease (PD), but studies on its utility are few. This study examines the validity and factor structure of MADRS in population with PD. In 104 patients with idiopathic PD, major depression was diagnosed by Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision; DSM-IV-TR) criteria, and all patients were rated by MADRS. The MADRS showed good concurrent validity with DSM-IV-TR criteria. The diagnostic cutoff was established as 16/17 (sensitivity 97.43, specificity 100%, positive predictive value 100%, and negative predictive value 98.48%). Factor analysis identified 3 factors, accounting for 76% of total variance: "sadness-anhedonia" comprising apparent sadness, reported sadness, concentration difficulties, lassitude, inability to feel, pessimistic thoughts, and suicidal ideas; "anxiety" with reduced sleep and inner tension; and "vegetative symptoms" with reduced appetite. The MADRS has diagnostic utility in major depression in PD. The 3-factor structure of MADRS may help to understand the different dimensions of major depression and identify distinct symptom subgroups in this population.
Citation	Journal of geriatric psychiatry and neurology 2016-05; 29(3): 115-9
ISSN	0891-9887
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/26392481/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5436
Subject	Parkinson disease depression geriatric psychiatry mental health
MESH subject	Adult Aged Aged, 80 and over Anhedonia Anxiety Anxiety Disorders Depression Depressive Disorder, Major Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Middle Aged Parkinson Disease Psychiatric Status Rating Scales Reproducibility of Results Sensitivity and Specificity Factor Analysis, Statistical
Title	Diagnostic Validity and Factor Analysis of Montgomery-Asberg Depression Rating Scale in Parkinson Disease Population.
Type of document	Journal Article Validation Study
Entity Type	Publication

Diagnostic Validity and Factor Analysis of Montgomery-Asberg Depression Rating Scale in Parkinson Disease Population.

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