Singh, Jagtar; Jayaraj, Rama; Baxi, Siddhartha; Mileva, Marina; Skinner, John; Dhand, Navneet K; Thomas, Mahiban

Author(s)

Singh, Jagtar

Jayaraj, Rama

Baxi, Siddhartha

Mileva, Marina

Skinner, John

Dhand, Navneet K

Thomas, Mahiban

Publication Date

2016-02-01

Abstract

Molecular markers can be used to identify residual cancer at the surgical margins of head and neck squamous cell carcinoma (HNSCC) and assist in evaluating the complete resection of the tumour. The purpose of the present study was to investigate the expression levels of prognostic molecular markers at the histological tumour free surgical margins. In the present clinical retrospective study, 24/48 patients were selected with negative surgical margins for further analysis with immunohistochemical staining. Contingency tables and Fisher's exact tests were used to investigate the association between the expression levels of p53 and eukaryotic translation imitation factor 4E (eIF4E) with the clinical outcomes for patients with HNSCC. The expression levels of p53 and eIF4E were 54.2 and 87.5%, respectively, in the surgical margins of patients with HNSCC. A total of 3/7 patients with recurrent cancer (42.8%) were identified with p53-positive margins, and 6 (85.7%) patients exhibited recurrence with eIF4e-positive margins. No statistically significant differences were identified for the recurrence risk between the overexpression of p53 and eIF4E in the surgical margins (P=0.88 and P=0.99, respectively). The eIF4E marker appears to be a more marked prognosticator compared with p53, as overexpression of eIF4E was identified in the margins of 6/7 patients with local recurrence.

Citation

Mol Clin Oncol . 2016 Feb;4(2):166-172. doi: 10.3892/mco.2015.689. Epub 2015 Dec 1.

ISSN

2049-9450

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/26893854/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5381

Subject

eukaryotic translation imitation factor 4E

immunohistochemistry

molecular markers

overall survival

p53

recurrence

Title

Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Singh, Jagtar Jayaraj, Rama Baxi, Siddhartha Mileva, Marina Skinner, John Dhand, Navneet K Thomas, Mahiban
Publication Date	2016-02-01
Abstract	Molecular markers can be used to identify residual cancer at the surgical margins of head and neck squamous cell carcinoma (HNSCC) and assist in evaluating the complete resection of the tumour. The purpose of the present study was to investigate the expression levels of prognostic molecular markers at the histological tumour free surgical margins. In the present clinical retrospective study, 24/48 patients were selected with negative surgical margins for further analysis with immunohistochemical staining. Contingency tables and Fisher's exact tests were used to investigate the association between the expression levels of p53 and eukaryotic translation imitation factor 4E (eIF4E) with the clinical outcomes for patients with HNSCC. The expression levels of p53 and eIF4E were 54.2 and 87.5%, respectively, in the surgical margins of patients with HNSCC. A total of 3/7 patients with recurrent cancer (42.8%) were identified with p53-positive margins, and 6 (85.7%) patients exhibited recurrence with eIF4e-positive margins. No statistically significant differences were identified for the recurrence risk between the overexpression of p53 and eIF4E in the surgical margins (P=0.88 and P=0.99, respectively). The eIF4E marker appears to be a more marked prognosticator compared with p53, as overexpression of eIF4E was identified in the margins of 6/7 patients with local recurrence.
Citation	Mol Clin Oncol . 2016 Feb;4(2):166-172. doi: 10.3892/mco.2015.689. Epub 2015 Dec 1.
ISSN	2049-9450
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/26893854/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5381
Subject	eukaryotic translation imitation factor 4E immunohistochemistry molecular markers overall survival p53 recurrence
Title	Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma.
Type of document	Journal Article
Entity Type	Publication

Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma.

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