| Author(s) |
Bergamin, Gianni
Hudson, Joshua
Currie, Bart J
Mounsey, Kate E
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| Publication Date |
2024-06-01
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| Abstract |
Objectives: Crusted scabies (CS, Norwegian scabies) is a severe form of scabies, characterized by hyper-infestation of Sarcoptes scabiei mites. CS is commonly associated with immunosuppression but is also reported in overtly immunocompetent individuals. We reviewed immunosuppressive risk factors and comorbidities associated with CS.
Methods: The National Library of Medicine (PubMed) database was reviewed for patient case reports of CS from January 1998 to July 2023. Two authors screened records for eligibility, extracted data, and one critically appraised the quality of the studies.
Systematic review registration: PROSPERO CRD42023466126.
Results: A total of 436 records were identified, of which 204 were included for systematic review. From these, 683 CS patients were included. CS impacted both genders equally. Adults (21-59 years) were more commonly affected (45.5%) compared to children (0-20 years, 21%). Corticosteroid use was the most prevalent immunosuppressive risk factor identified (27.7% of all cases). About 10.2% of reports were associated with HIV/AIDS, and 8.5% with HTLV-1 infection. 10.5% of patients were overtly immunocompetent with no known risk factors. Overall, 41 (6.0%) died, many subsequent to secondary bacteremia.
Conclusion: This study represents the first systematic review undertaken on immunosuppressive risk factors associated with CS. This provides insights into trends of immunosuppression and mechanisms of CS development.
|
| Affiliation |
School of Health, University of the Sunshine Coast, Queensland, Australia; School of Medicine and Dentistry, Griffith University, Birtinya, Queensland, Australia; Sunshine Coast Health Institute, Birtinya, Queensland, Australia.
School of Health, University of the Sunshine Coast, Queensland, Australia; School of Medicine and Dentistry, Griffith University, Birtinya, Queensland, Australia; Sunshine Coast Health Institute, Birtinya, Queensland, Australia.
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Infectious Diseases, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
School of Health, University of the Sunshine Coast, Queensland, Australia; Sunshine Coast Health Institute, Birtinya, Queensland, Australia. Electronic address: kmounsey@usc.edu.au.
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| Citation |
Bergamin G, Hudson J, Currie BJ, Mounsey KE. A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies. Int J Infect Dis. 2024 Jun;143:107036. doi: 10.1016/j.ijid.2024.107036. Epub 2024 Apr 1. PMID: 38570134.
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| ISSN |
1878-3511
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| Pubmed ID |
https://pubmed.ncbi.nlm.nih.gov/38570134/?otool=iaurydwlib
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| Link | |
| Subject |
Crusted scabies
HIV
HTLV-1
Immunosuppression
Norwegian scabies
Risk factors
Sarcoptes scabiei
Scabies
|
| MESH subject |
Scabies
Humans
Risk Factors
Comorbidity
Female
Male
Adult
Immunocompromised Host
Middle Aged
Young Adult
Adolescent
Child
Animals
Infant
Sarcoptes scabiei
HIV Infections
Child, Preschool
HTLV-I Infections
Immunosuppression Therapy
Infant, Newborn
|
| Title |
A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies.
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| Type of document |
Journal Article
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| Entity Type |
Publication
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| Name | Size | format | Description | Link |
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