Marangou, James

Ferguson, Dominic

Unger, Holger

Kaethner, Alexander

Ilton, Marcus

Remenyi, Bo

Ralph, Anna

2024-09-01

Rheumatic heart disease (RHD) remains prevalent within First Nations Australian communities. RHD is more common in females and peak prevalence corresponds with childbearing age. Significant valvular disease can complicate pregnancy. Current practice in Northern Australia is to refer pregnant women for echocardiography if there are signs or symptoms of possible cardiac pathology or a history of acute rheumatic fever (ARF) or RHD. It is not currently routine practice to offer echocardiographic screening for all pregnant women at high risk of RHD.This study aimed to assess the current referral practices for echocardiography and disease patterns in pregnant women in the Northern Territory, Australia-a region with a known high prevalence of RHD in the First Nations population.A retrospective analysis of all echocardiography referrals of pregnant women over a 4-year period was performed. Data included indication for echocardiography, clinical history, echocardiographic findings, and location of delivery. Comparisons were made using Fisher's exact and Mann-Whitney U tests.A total of 322 women underwent echocardiography during pregnancy: 195 First Nations and 127 non-Indigenous women (median age, 25 vs 30 years, respectively; p<0.01). Indications for echocardiography differed by ethnicity, with history of ARF or RHD being the most common indication in First Nations women, and incidental murmur the most common in non-Indigenous women. First Nations women were more likely to have abnormal echocardiograms (35.9% vs 11.0% in non-Indigenous women; p<0.01) or a history of ARF or RHD (39.5% vs 0.8%; p<0.01), but less likely to have documented cardiac symptoms as an indication for echocardiography (8.2% vs 20.5%; p<0.01). New cardiac diagnoses were made during pregnancy in 11 (5.6%) First Nations and two (1.6%) non-Indigenous women (p=0.02). Moderate or severe valve lesions were detected in 26 (13.3%) First Nations women (all previously diagnosed), and 11 (5.6%) had previous cardiac surgery. No severe valve lesions were identified in the non-Indigenous group. Interstate transfer to a tertiary centre with valve intervention services was required during pregnancy or the puerperium for 12 (6.2%) First Nations women and no non-Indigenous women.Amongst pregnant women in the Northern Territory who had an indication for echocardiography, First Nations women were more likely to have abnormal echocardiograms. This was mainly due to valvular disease secondary to RHD. Cardiac symptoms were infrequently recorded as an indication for echocardiography in First Nations women, suggesting possible underappreciation of symptoms. Having a low threshold for echocardiographic investigation, including consideration of universal screening during pregnancy, is important in a high RHD-burden setting such as ours. A better understanding of the true prevalence and spectrum of disease severity in this population would enable health services to invest in appropriate resources.

Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia. Electronic address: james.marangou@menzies.edu.au.

Departments of Medicine, Paediatrics and Obstetrics, Royal Darwin Hospital, Darwin, NT, Australia.

Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Departments of Medicine, Paediatrics and Obstetrics, Royal Darwin Hospital, Darwin, NT, Australia; Liverpool School of Tropical Medicine, Liverpool, UK.

Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Departments of Medicine, Paediatrics and Obstetrics, Royal Darwin Hospital, Darwin, NT, Australia.

Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Departments of Medicine, Paediatrics and Obstetrics, Royal Darwin Hospital, Darwin, NT, Australia.

Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Departments of Medicine, Paediatrics and Obstetrics, Royal Darwin Hospital, Darwin, NT, Australia.

Heart Lung Circ . 2024 Sep;33(9):1307-1313. doi: 10.1016/j.hlc.2024.04.301. Epub 2024 Jun 25.

1444-2892

https://pubmed.ncbi.nlm.nih.gov/38918121/?otool=iaurydwlib

https://hdl.handle.net/10137/13604

Echocardiography

First Nations Australians

Obstetric-cardiology

Pregnancy

Rheumatic heart disease

Humans

Female

Pregnancy

Adult

Echocardiography

Retrospective Studies

Rheumatic Heart Disease

Pregnancy Complications, Cardiovascular

Northern Territory

Australia

Assessing the Role of Echocardiography in Pregnancy in First Nations Australian Women: Is it an Underutilised Resource?

Journal Article

Publication