Title
In-hospital mortality in patients admitted to Australian intensive care units with COVID-19 between 2020 and 2024.
Author(s)
Donnan, Matthew T
Zhao, Peinan
Cheng, Allen C
Ibrahim, Aaliya
Palermo, Annamaria
Reddi, Benjamin
Reynolds, Claire
French, Craig
Litton, Edward
Rotherham, Hannah
Begum, Husna
Cooper, Jamie
Dumbrell, Jodi
Plummer, Mark
Ramanan, Mahesh
Alliegro, Patricia
McAllister, Richard E
Erickson, Simon
Priyadarshini, Shweta
Ng, Sze
Broadley, Tessa
Trapani, Tony
Papanikolaou, Vicki
Cheung, Winston
Udy, Andrew A
Burrell, Aidan
Abstract
To describe and compare the demographics, management, and outcomes for patients with COVID-19 admitted to intensive care units (ICUs) in Australia across the various waves of the COVID pandemic.People aged ≥16 years who were admitted to a participating ICU with confirmed COVID-19 in the Short Period Incidence Study of Severe Acute Respiratory Infection (SPRINT-SARI) Australia study between February 2020 and May 2024.Primary outcome: In-hospital mortality. Secondary outcomes: ICU mortality; ICU and hospital lengths of stay; supportive and disease-specific therapies.From 27 February 2020 to 18 May 2024, 10171 people were admitted to 72 ICUs with confirmed COVID-19 disease. The ave included 518 (5.1%) patients, the wave 2467 (24.3%) patients, and the wave 7186 (70.7%) patients. The median (IQR) age was 61 (49-70) years, 54 (41-66) years, and 65 (45-75) years, respectively (P < 0.001). The proportion of vaccinated cases increased in successive waves (1% vs 23.9% vs 65.1%) but plateaued in the subvariant waves (range 60.0%-71.9%). Invasive mechanical ventilation use decreased across successive waves (52.5% vs 43.6% vs 31.7%, P < 0.001). Use of extracorporeal membrane oxygenation was highest during the wave (3.6%, 83 patients, median duration 18 days [IQR 9.8-35]). Multivariable analysis demonstrated an increased risk of in-hospital mortality among patients admitted during the D (adjusted HR 1.80, 95% CI: 1.38-2.35, < 0.001) and (adjusted HR 1.88, 95% CI: 1.46-2.42, < 0.001) waves when compared to the wave.COVID-19 continues to manifest significant morbidity and mortality in those requiring ICU admission. Despite a reduced need for ICU level supports, patients admitted during the wave demonstrated the highest in-hospital mortality.
Publication information
Crit Care Resusc . 2025 Feb 28;27(1):100094. doi: 10.1016/j.ccrj.2024.11.003. eCollection 2025 Mar.
Date Issued
2025-02-28
Type
Journal Article
Journal Title
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
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