Barr ELM

Cunningham J

Tatipata S

Dunbar T

Kangaharan N

Guthridge S

Li SQ

Condon JR

Shaw JE

O'Dea K

Maple-Brown LJ

2017-07

To assess the relationships of diabetes and albuminuria with all-cause mortality and cardiovascular disease outcomes in a population without prior cardiovascular disease using data from the Darwin Region Urban Indigenous Diabetes (DRUID) study. We conducted a prospective cohort study of 706 participants (aged 15-81 years, 68% women) without prior cardiovascular disease who underwent a 75-g oral glucose tolerance test. Deaths and fatal or non-fatal cardiovascular disease were determined over 7 years, and hazard ratios with 95% CIs and population attributable risks were estimated for baseline glycaemia and albuminuria. Compared with normoglycaemia and after adjustment for age, sex, hypertension, dyslipidaemia and smoking, known diabetes was associated with an adjusted hazard ratio of 4.8 (95% CI 1.5-14.7) for all-cause mortality and 5.6 (95% CI 2.1-15.2) for cardiovascular disease. Compared with normoalbuminuria, the respective adjusted risks for macroalbuminuria were 10.9 (95% CI 3.7-32.1) and 3.9 (95% CI 1.4-10.8). The Adjusted all-cause mortality and cardiovascular disease estimated population attributable risks for diabetes were 27% and 32%, and for albuminuria they were 32% and 21%, respectively. In our study population, the burden of mortality and cardiovascular disease was largely driven by diabetes and albuminuria. This finding on the influence of diabetes and albuminuria is consistent with reports in other high-risk Indigenous populations and should be better reflected in risk scores and intervention programmes.

Diabetic medicine : a journal of the British Diabetic Association 2017-07; 34(7): 946-957

http://orcid.org/0000-0003-4284-1716

https://pubmed.ncbi.nlm.nih.gov/28375555/?otool=iaurydwlib

https://hdl.handle.net/10137/5254

Adolescent

Adult

Aged

Albuminuria

Australia

Cardiovascular Diseases

Cohort Studies

Diabetic Angiopathies

Diabetic Cardiomyopathies

Diabetic Nephropathies

Female

Follow-Up Studies

Health Surveys

Humans

Incidence

Male

Mortality

Oceanic Ancestry Group

Prevalence

Proportional Hazards Models

Prospective Studies

Renal Insufficiency, Chronic

Risk Factors

Urban Health

Associations of mortality and cardiovascular disease risks with diabetes and albuminuria in urban Indigenous Australians: the DRUID follow-up study.

Journal Article

Observational Study

Publication