Whiley DM

Trembizki E

Buckley C

Freeman K

Baird RW

Beaman M

Chen M

Donovan B

Kundu RL

Fairley CK

Guy R

Hogan T

Kaldor JM

Karimi M

Limnios A

Regan DG

Ryder N

Su J-Y

Ward J

Lahra MM

2017-09

Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N. gonorrhoeae AMR PCR assays. We compared results with those from routine culture-based surveillance data. PCR data confirmed an absence of ceftriaxone resistance and a low level of azithromycin resistance (0.2%), and that penicillin resistance was <5% in amoxicillin plus azithromycin regions. Rates of ciprofloxacin resistance and penicillinase-producing N. gonorrhoeae were lower when molecular methods were used. Molecular methods to detect N. gonorrhoeae AMR can increase the evidence base for treatment guidelines, particularly in settings where culture-based surveillance is limited.

Emerg Infect Dis. 2017 Sep;23(9):1478-1485. doi: 10.3201/eid2309.170427.

https://pubmed.ncbi.nlm.nih.gov/28820128/?otool=iaurydwlib

https://hdl.handle.net/10137/11447

23

Adult

Amoxicillin/therapeutic use

Anti-Bacterial Agents/*therapeutic use

Azithromycin/therapeutic use

Ceftriaxone/therapeutic use

Ciprofloxacin/therapeutic use

Drug Resistance, Bacterial/*genetics

Female

Gonorrhea/drug therapy/*epidemiology/microbiology/transmission

Humans

Male

Microbial Sensitivity Tests

Middle Aged

Molecular Epidemiology

Multilocus Sequence Typing

Neisseria gonorrhoeae/drug effects/*genetics/isolation & purification

Northern Territory/epidemiology

Penicillins/therapeutic use

*Public Health Surveillance

Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia.

Journal Article

Publication