Frommer DJ

Fernandes, David

Pawar G

Goud R

2014-06-01

This study documents the symptoms, racial distribution, pathological findings and outcomes of patients diagnosed with gastrointestinal amyloidosis in Alice Springs Hospital. In a 4 year retrospective survey. 9 patients, all indigenous, 7F/2M, had biopsy proven gastrointestinal amyloidosis. Four out of four patients tested were found to have AA amyloidosis. Presenting symptoms included diarrhoea, bloody in some, vomiting and abdominal pain. All but one had diabetes mellitus, type 2. Multiple infections were common and most patients had low serum albumin and transferrin concentrations but high serum ferritin concentrations. Five of the patients died, and the gastrointestinal symptoms of the remaining 4 remitted. Gastrointestinal amyloidosis should be included in the differential diagnosis of indigenous patients presenting with chronic diarrhoea, vomiting or abdominal pain. It carries a grave prognosis, is probably secondary to chronic infections but is potentially reversible.

Internal medicine journal 2014-06; 44(6): 605-9

https://pubmed.ncbi.nlm.nih.gov/24946817/?otool=iaurydwlib

https://hdl.handle.net/10137/5581

amyloidosis

indigenous

pathology

prognosis

symptom

Abdominal Pain

Adult

Aged

Aged, 80 and over

Amyloidosis

Bacterial Infections

C-Reactive Protein

Candidiasis

Cardiovascular Diseases

Comorbidity

Deltaretrovirus Infections

Diabetes Mellitus, Type 2

Diarrhea

Dyslipidemias

Female

Ferritins

Gastrointestinal Diseases

Gastrointestinal Hemorrhage

Humans

Hypoalbuminemia

Male

Middle Aged

Northern Territory

Prognosis

Renal Insufficiency, Chronic

Serum Amyloid A Protein

Transferrin

Vomiting

Oceanic Ancestry Group

Gastrointestinal amyloidosis in Australian indigenous patients.

Journal Article

Publication