Talukder MR

Woodman R

Pham H

Wilson K

Gessain A

Kaldor J

Einsiedel, Lloyd

2023-02-08

BACKGROUND: A link between chronic inflammation and several noncommunicable diseases (NCDs) has been established. Although chronic infection with the human T-cell leukemia virus type 1 (HTLV-1) is the recognized cause of several inflammatory diseases and these are associated with a high number of HTLV-1-infected cells in peripheral blood (proviral load [PVL]), possible interactions between PVL and NCDs have not been studied at a community level. METHODS: Adult Aboriginal residents of 7 remote communities were invited to complete a health survey between 25 August 2014 and 30 June 2018. Blood was drawn for HTLV-1 serology and PVL, and relevant medical conditions were obtained from health records. Associations between HTLV-1 PVL and diabetes, chronic kidney disease (CKD), and coronary artery disease (CAD) were determined using logistic regression, adjusting for available confounders. RESULTS: Among 510 participants (56% of the estimated adult resident population, 922), 197 (38.6%) were HTLV-1-infected. A high HTLV-1 PVL was associated with a 2-fold increase in the odds of diabetes and CKD (diabetes, adjusted odds ratio [aOR], 1.95; 95% confidence interval [CI], 1.06-3.61; P = .033 and CKD: aOR, 2.00; 95% CI, 1.03-3.8; P = .041). A nonsignificant association between high PVL and CAD (aOR, 7.08; 95% CI, 1.00-50.18; P = .05) was found for participants aged <50 years at the time of angiography. CONCLUSIONS: In a community-based study in central Australia, people with HTLV-1 who had high HTLV-1 PVL were more likely to have diabetes and CKD. These findings have potential clinical implications.

HTLV-1 Research, Baker Heart and Diabetes Institute, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

National Serology Reference Laboratory, Melbourne, Australia.

Oncogenic Virus Epidemiology and Pathophysiology (EPVO) Unit and Joint Research Unit (UMR) 3569 National Reference Centre (CNRS), Virology Department, Institut Pasteur, Paris, France.

Global Health Program, Kirby Institute, University of New South Wales, Sydney, Australia.

Department of Medicine, NT Health, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

Clin Infect Dis. 2023 Feb 8;76(3):e820-e826. doi: 10.1093/cid/ciac614.

0000-0002-8343-9777

0000-0002-2517-6083

https://pubmed.ncbi.nlm.nih.gov/35903021/?otool=iaurydwlib

https://hdl.handle.net/10137/12399

76

Adult

Humans

Proviruses

*HTLV-I Infections/complications/epidemiology

Cross-Sectional Studies

*Human T-lymphotropic virus 1

*Diabetes Mellitus

Australia/epidemiology

*Renal Insufficiency, Chronic/epidemiology/complications

Viral Load

Surveys and Questionnaires

*Leukemia, T-Cell/complications

High Human T-Cell Leukemia Virus Type 1c Proviral Loads Are Associated With Diabetes and Chronic Kidney Disease: Results of a Cross-Sectional Community Survey in Central Australia.

Journal Article

Publication