Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012.

2013-09-03

Lai, Jana Yr

Cook, Heather

Yip, Teem-Wing

Berthelsen, Jeanette

Gourley, Stephen

Krause, Vicki

Smith, Helen

Leach, Amanda

Smith-Vaughan, Heidi

Adolescent

Adult

Aged

Australia

Carrier State

Child

Child, Preschool

Disease Outbreaks

Epidemiological Monitoring

Female

Humans

Infant

Male

Middle Aged

Nasopharynx

Pneumococcal Infections

Streptococcus pneumoniae

Young Adult

Journal Article

Publication

BACKGROUND: An outbreak of serotype 1 invasive pneumococcal disease (IPD) occurred in Central Australia from October 2010 to the latter part of 2012. Surveillance of serotype 1 carriage was conducted to determine epidemiological features of asymptomatic carriage that could potentially be driving the outbreak. METHODS: 130 patients and accompanying persons presenting at Alice Springs Hospital Emergency Department consented to nasopharyngeal swab (NPS) collection. NPS were processed by standard methods, including culture, pneumococcal lytA quantitative real-time PCR, serotype 1-specific real-time PCR and multi-locus sequence typing (MLST). RESULTS: Pneumococcal carriage was detected in 16% of participants. Carriage was highest in the under 10 year olds from remote communities surrounding Alice Springs (75%). Four NPS were positive for serotype 1 DNA by PCR; 3 were also culture-positive for serotype 1 pneumococci. Serotype 1 isolates had atypical colony morphology on primary culture. All serotype 1 carriers were healthy children 5 to 8 years of age from remote communities. By MLST, serotype 1 isolates were ST306, as were IPD isolates associated with this outbreak. CONCLUSIONS: During an outbreak of serotype 1 ST306 IPD, carriage of the outbreak strain was detected in 3% NPS collected. All carriers were healthy children 5 to 8 years of age.

link

BMC Infect Dis . 2013 Sep 3:13:409. doi: 10.1186/1471-2334-13-409.

1471-2334

1471-2334

https://pubmed.ncbi.nlm.nih.gov/24138669/?otool=iaurydwlib