Ekinci EI

Barr ELM

Barzi F

Hughes JT

Lawton PD

Jones GRD

Hoy W

Cass A

Thomas, Mark

Sinha A

Jerums G

O'Dea K

MacIsaac RJ

Maple-Brown LJ

2019-05

Glomerular hyperfiltration is not able to be detected in clinical practice. We assessed whether hyperfiltration is associated with albuminuria progression among Indigenous Australians at high risk of diabetes and kidney disease to determine its role in kidney disease progression. Longitudinal observational study of Indigenous Australians aged ≥18 years recruited from >20 sites, across diabetes and/or kidney function strata. At baseline, iohexol clearance was used to measure glomerular filtration rate (mGFR) and hyperfiltration was defined as (i) a mGFR of ≥125 mL/min/1.73 m2, and (ii) an age-adjusted definition, with the top 10% of the mGFR for each 10 year age group at baseline. Baseline and follow-up urine albumin-to-creatinine ratio (uACR) was collected, and linear regression was used to assess the associations of hyperfiltration and uACR at follow up. 407 individuals (33% men, mean age 47 years) were followed-up for a median of 3 years. At baseline, 234 had normoalbuminuria and 173 had albuminuria. Among participants with normoalbuminuria, those with mGFR ≥125 mL/min/1.73 m2 had 32% higher uACR at follow-up (p = 0.08), and those with age-adjusted hyperfiltration had 60% higher uACR (p = 0.037) compared to those who had normofiltration. These associations were independent of uACR at baseline, but attenuated by HbA1c. Associations were stronger among those without than those with albuminuria at baseline. Although not available for assessment in current clinical practice, hyperfiltration may represent a marker of subsequent albuminuria progression among individuals who have not yet developed albuminuria.

Menzies School of Health Research, Charles Darwin University, Australia; The University of Melbourne, Department of Medicine at Austin Health, Melbourne, Australia; Department of Endocrinology, Austin Health, Melbourne, Australia..

Menzies School of Health Research, Charles Darwin University, Australia; Baker Heart and Diabetes Institute, Melbourne, Australia..

Menzies School of Health Research, Charles Darwin University, Australia..

Menzies School of Health Research, Charles Darwin University, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia..

Menzies School of Health Research, Charles Darwin University, Australia..

SydPath, St Vincent's Hospital, Sydney, Australia; University of New South Wales Sydney, Sydney, Australia..

The University of Queensland Centre for Chronic Disease, Queensland, Australia..

Menzies School of Health Research, Charles Darwin University, Australia..

Royal Perth Hospital, Perth, Australia..

Diabetes and Endocrinology, Cairns Base Hospital, Cairns, Australia..

Menzies School of Health Research, Charles Darwin University, Australia; The University of Melbourne, Department of Medicine at Austin Health, Melbourne, Australia..

The University of Melbourne, Department of Medicine at Austin Health, Melbourne, Australia; School of Population Health, University of South Australia, Australia..

Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne and the University of Melbourne, Melbourne, Australia..

Menzies School of Health Research, Charles Darwin University, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia. Electronic address: Louise.Maple-Brown@menzies.edu.au..

Journal of diabetes and its complications 2019-05; 33(5): 343-349

https://pubmed.ncbi.nlm.nih.gov/30904420/?otool=iaurydwlib

https://hdl.handle.net/10137/7527

Albuminuria

Chronic kidney disease

Diabetic kidney disease

Diabetic nephropathy

Hyperfiltration

Indigenous Australians

Is hyperfiltration associated with higher urine albumin-to-creatinine ratio at follow up among Indigenous Australians? The eGFR follow-up study.

Journal Article

Publication