Enkel, Stephanie L

Barnes, Samuel

Daw, Jessica

Pearson, Emma

Thomas, Hannah M M

Lansbury, Nina

Wyber, Rosemary

Redmond, Andrew M

Ralph, Anna

Carapetis, Jonathan R

Bowen, Asha C

2024-03-12

Despite being the sixth most common infectious disease globally, transmission of Streptococcus pyogenes (Strep A) within the household remains an understudied driver of infection. We undertook a systematic review to better understand the transmission of Strep A between people within the home while highlighting opportunities for prevention.A search strategy was applied to five databases between September 2022 and March 2023. Results were limited to those published between January 2000 and March 2023. Texts were reviewed by two authors and the following data extracted: article details (title, author, year), study type, transmission year, country, participant age/s, infection status, molecular testing, and transmission mode. Funding was provided by the Australian National Health and Medical Research Council (NHMRC, grant number GNT2010716).The final analysis comprised 28 texts. Only seven studies (25.0%) provided sufficient detail to identify the Strep A transmission mode. These were contact (4), vehicle (bedding; clothing; other fabric, and medical equipment, [2]), and contact with animals (1). All others were classified as household (specific mode unascertainable). Most articles reported outbreaks involving invasive Strep A infections.There is limited literature regarding household transmission of Strep A. Understanding transmission in this setting remains imperative to guide control methods.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

Medical School, University of Western Australia, Crawley, WA, Australia.

School of Public Health, University of Queensland, Brisbane, QLD, Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

School of Public Health, University of Queensland, Brisbane, QLD, Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

National Centre for Aboriginal and Torres Strait Islander Wellbeing Research, The Australian National University, Canberra, ACT, Australia.

School of Public Health, University of Queensland, Brisbane, QLD, Australia.

Department of Infectious Diseases Unit, Metro North Hospital and Health Service, QLD, Health, Brisbane, Queensland, Australia.

Department of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Menzies School of Health Research, Darwin, NT, Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

Medical School, University of Western Australia, Crawley, WA, Australia.

Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, Australia.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA  Australia.

Medical School, University of Western Australia, Crawley, WA, Australia.

Menzies School of Health Research, Darwin, NT, Australia.

Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA, Australia.

J Infect Dis . 2024 Mar 13:jiae136. doi: 10.1093/infdis/jiae136. Online ahead of print.

1537-6613

https://pubmed.ncbi.nlm.nih.gov/38478731/?otool=iaurydwlib

https://hdl.handle.net/10137/13272

Streptococcus pyogenes

households

transmission

Systematic review of household transmission of Strep A: A potential site for prevention that has eluded attention.

Journal Article

Publication