Parker C; Tong Steven; Dempsey, Karen; Condon J; Sharma SK; Chen JWC; Sievert W; Davis JS

Author(s)

Parker C

Tong Steven

Dempsey, Karen

Condon J

Sharma SK

Chen JWC

Sievert W

Davis JS

Publication Date

2014-10-20

Abstract

To describe the epidemiology, clinical features, management and outcomes of hepatocellular carcinoma (HCC) in the Northern Territory over the past decade. An NT-wide epidemiology study covering the period 1991-2010 and a clinical cohort study including patients diagnosed during 2000-2011. HCC diagnoses were provided by the NT Cancer Registry and cross-checked against clinical records. Age-adjusted incidence of HCC; management; clinical features; and median and 1-year survival. There were 145 incident cases of HCC in the NT during 1991-2010, giving an age-adjusted annual incidence of 22.7/100 000 (95% CI, 17.2-26.8) for Indigenous Australians and 4.0/100 000 (95% CI, 2.1-5.8) for non-Indigenous Australians - an incidence rate ratio of 5.9 (95% CI, 4.7-7.4). There was no significant change in annual age-adjusted incidence over this period. The most common causative factors were hepatitis B virus in Indigenous people and hepatitis C virus in non-Indigenous people. Most people were diagnosed late, only 13/80 were diagnosed by screening, and outcomes were poor, with 28/80 overall surviving to 1 year. Outcomes were better among those managed through a centralised multidisciplinary service than among those who were not (adjusted hazard ratio for death at 1 year, 0.35 [95% CI, 0.16-0.81]). HCC incidence remains high in the Indigenous people of the NT. More resources are needed for HCC surveillance and management programs in this population.

Citation

Med J Aust . 2014 Oct 20;201(8):470-4. doi: 10.5694/mja13.11117.

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/25332035/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5548

MESH subject

Age Distribution

Aged

Carcinoma, Hepatocellular

Combined Modality Therapy

Female

Follow-Up Studies

Humans

Incidence

Liver Neoplasms

Male

Middle Aged

Neoplasm Staging

Northern Territory

Prognosis

Retrospective Studies

Risk Assessment

Risk Factors

Survival Rate

Time Factors

Title

Hepatocellular carcinoma in Australia's Northern Territory: high incidence and poor outcome.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Parker C Tong Steven Dempsey, Karen Condon J Sharma SK Chen JWC Sievert W Davis JS
Publication Date	2014-10-20
Abstract	To describe the epidemiology, clinical features, management and outcomes of hepatocellular carcinoma (HCC) in the Northern Territory over the past decade. An NT-wide epidemiology study covering the period 1991-2010 and a clinical cohort study including patients diagnosed during 2000-2011. HCC diagnoses were provided by the NT Cancer Registry and cross-checked against clinical records. Age-adjusted incidence of HCC; management; clinical features; and median and 1-year survival. There were 145 incident cases of HCC in the NT during 1991-2010, giving an age-adjusted annual incidence of 22.7/100 000 (95% CI, 17.2-26.8) for Indigenous Australians and 4.0/100 000 (95% CI, 2.1-5.8) for non-Indigenous Australians - an incidence rate ratio of 5.9 (95% CI, 4.7-7.4). There was no significant change in annual age-adjusted incidence over this period. The most common causative factors were hepatitis B virus in Indigenous people and hepatitis C virus in non-Indigenous people. Most people were diagnosed late, only 13/80 were diagnosed by screening, and outcomes were poor, with 28/80 overall surviving to 1 year. Outcomes were better among those managed through a centralised multidisciplinary service than among those who were not (adjusted hazard ratio for death at 1 year, 0.35 [95% CI, 0.16-0.81]). HCC incidence remains high in the Indigenous people of the NT. More resources are needed for HCC surveillance and management programs in this population.
Citation	Med J Aust . 2014 Oct 20;201(8):470-4. doi: 10.5694/mja13.11117.
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/25332035/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5548
MESH subject	Age Distribution Aged Carcinoma, Hepatocellular Combined Modality Therapy Female Follow-Up Studies Humans Incidence Liver Neoplasms Male Middle Aged Neoplasm Staging Northern Territory Prognosis Retrospective Studies Risk Assessment Risk Factors Survival Rate Time Factors
Title	Hepatocellular carcinoma in Australia's Northern Territory: high incidence and poor outcome.
Type of document	Journal Article
Entity Type	Publication

Hepatocellular carcinoma in Australia's Northern Territory: high incidence and poor outcome.

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