Chang, A B

Harrhy, V A

Simpson, J

Masters, I B

Gibson, P G

2002-04-01

Prospective data on the temporal relation between cough, asthma symptoms, and airway inflammation in childhood asthma is unavailable. Using several clinical (diary, quality of life), lung function (FEV(1), FEV(1) variability, airway hyperresponsiveness), cough (diary, cough receptor sensitivity (CRS)), and inflammatory markers (sputum interleukin 8, eosinophilic cationic protein (ECP), myeloperoxidase; and serum ECP) of asthma severity, we prospectively described the course of these markers in children with asthma during a non-acute, acute, and resolution phase. A total of 21 children with asthma underwent these baseline tests; 11 were retested during days 1, 3, 7, and 28 of an exacerbation. Asthma exacerbations were characterised by increased asthma and cough symptoms and eosinophilic inflammation. Sputum ECP showed the largest increase and peaked later than clinical scores. Asthma scores consistently related to cough score only early in the exacerbation. Neither CRS nor cough scores related to any inflammatory marker. In mild asthma exacerbations, eosinophilic inflammation is dominant. In asthmatic children who cough as a dominant symptom, cough heralds the onset of an exacerbation and increased eosinophilic inflammation, but cough scores and CRS do not reflect eosinophilic airway inflammation.

Arch Dis Child . 2002 Apr;86(4):270-5. doi: 10.1136/adc.86.4.270.

https://pubmed.ncbi.nlm.nih.gov/11919102/?otool=iaurydwlib

https://hdl.handle.net/10137/6813

Acute Disease

Adolescent

Asthma

Bronchitis

Child

Child, Preschool

Cough

Female

Forced Expiratory Volume

Humans

Male

Prospective Studies

Pulmonary Eosinophilia

Quality of Life

Sputum

Vital Capacity

Cough, airway inflammation, and mild asthma exacerbation.

Journal Article

Publication