Hannah, Rory

Mitri, Elise

Katelaris, Constance H

O'Hern, Jennifer

Avent, Minyon

Valoppi, Glenn

Rawlins, Matthew

Frith, Catherine

McMullan, Brendan

Kong, David

Chua, Kyra

Legg, Amy

James, Rod

Janson, Sonja

Hawkins, Carolyn

Randall, Katrina

Ierano, Courtney

Thursky, Karin

Trubiano, Jason A

2024-10-23

Penicillin allergy is a significant burden on patient, prescribing and hospital outcomes. There has been increasing interest in the incorporation of penicillin allergy testing (i.e. delabelling) into antimicrobial stewardship (AMS) programmes to reduce the burden of penicillin allergy labels and improve prescribing. In particular, there has been a focus on point-of-care penicillin allergy assessment and direct oral challenge for low-risk phenotypes. The National Antibiotic Allergy Network has provided a guide to assist AMS clinicians with the incorporation of penicillin allergy programmes, in particular direct oral challenge, into Australian hospitals.

Department of Infectious Diseases, Clinical Immunology and Allergy, Division of Medicine, Lyell McEwin Hospital, Adelaide, South Australia, Australia.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Melbourne, Victoria, Australia.

Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Immunology/Allergy Unit, Department of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia.

Department of Infectious Diseases, Launceston General Hospital, Launceston, Tasmania, Australia.

Queensland Statewide Antimicrobial Stewardship Program, Queensland Health, Brisbane, Queensland, Australia.

Faculty of Medicine, University of Queensland Centre for Clinical Research (UQCCR), University of Queensland, Brisbane, Queensland, Australia.

Slade Pharmacy, Epworth Healthcare, Melbourne, Victoria, Australia.

Department of Pharmacy, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Department of Immunology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Department of Infectious Diseases, Sydney Children's Hospital, Sydney, New South Wales, Australia.

School of Clinical Medicine, Discipline of Paediatrics, University of New South Wales, Sydney, New South Wales, Australia.

Department of Infectious Diseases, National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Melbourne, Victoria, Australia.

Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Department of Infectious Diseases, National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Microbiological Diagnostic Unit - Public Health Laboratory, Peter Doherty Institute for Infection and Immunology, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.

Royal Melbourne Hospital Guidance Group, Melbourne Health, Melbourne, Victoria, Australia.

Department of Infectious Diseases, Royal Darwin Hospital and Northern Territory Medical Program, Darwin, Northern Territory, Australia.

Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.

School of Medicine and Psychology, Australian National University, Canberra, Australian Capital Territory, Australia.

Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.

School of Medicine and Psychology, Australian National University, Canberra, Australian Capital Territory, Australia.

Department of Infectious Diseases, National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Royal Melbourne Hospital Guidance Group, Melbourne Health, Melbourne, Victoria, Australia.

Department of Infectious Diseases, National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Royal Melbourne Hospital Guidance Group, Melbourne Health, Melbourne, Victoria, Australia.

National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Melbourne, Victoria, Australia.

Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

Intern Med J . 2024 Oct 23. doi: 10.1111/imj.16543. Online ahead of print.

1445-5994

0000-0002-1250-2847

0000-0002-6525-1084

0000-0002-5111-6367

https://pubmed.ncbi.nlm.nih.gov/39444148/?otool=iaurydwlib

https://hdl.handle.net/10137/13754

antimicrobial allergy

beta‐lactam allergy

delabelling

oral challenge

penicillin allergy

Adult penicillin allergy programmes in Australian hospitals: a practical guide from the National Antibiotic Allergy Network.

Journal Article

Publication