Cheng AC

Stephens, Dianne

Anstey, Nicholas

Currie, Bart

2004-01-01

Melioidosis, caused by the intracellular pathogen Burkholderia pseudomallei, is endemic in northern Australia and Southeast Asia. Risk factors for this infection have also been associated with functional neutrophil defects. Because of this, granulocyte colony-stimulating factor (G-CSF) was adopted for use in patients with septic shock due to melioidosis in December 1998. We compared the mortality rates from before and after the introduction of G-CSF therapy at the Royal Darwin Hospital (Darwin, Australia) during the period of 1989-2002. The mortality rate decreased from 95% to 10% after the introduction of G-CSF. Risk factors, the duration of illness before presentation, and the severity of illness were similar in both groups. A smaller decrease in mortality among patients in the intensive care unit who did not have melioidosis was observed, suggesting that other changes in management did not account for the magnitude of the benefit seen. We conclude that G-CSF may have contributed to the reduction in the mortality rate among patients with septic shock due to melioidosis.

Clin Infect Dis . 2004 Jan 1;38(1):32-7. doi: 10.1086/380456. Epub 2003 Dec 4.

https://pubmed.ncbi.nlm.nih.gov/14679445/?otool=iaurydwlib

https://hdl.handle.net/10137/5845

Adolescent

Adult

Child

Female

Granulocyte Colony-Stimulating Factor

Humans

Intensive Care Units

Male

Melioidosis

Middle Aged

Shock, Septic

Thienamycins

Burkholderia pseudomallei

Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis.

Journal Article

Publication