Hughes Wagadagam , Jaquelyne; Barzi F; Hoy WE; Jones GRD; Rathnayake G; Majoni, Sandawana William; Thomas, Mark AB; Sinha A; Cass A; MacIsaac RJ; O'Dea K; Maple-Brown, Louise

Author(s)

Hughes Wagadagam , Jaquelyne

Barzi F

Hoy WE

Jones GRD

Rathnayake G

Majoni, Sandawana William

Thomas, Mark AB

Sinha A

Cass A

MacIsaac RJ

O'Dea K

Maple-Brown, Louise

Publication Date

2017-12-01

Abstract

Low serum bilirubin concentrations are reported to be strongly associated with cardio-metabolic disease, but this relationship has not been reported among Indigenous Australian people who are known to be at high risk for diabetes and chronic kidney disease (CKD). serum bilirubin will be negatively associated with markers of chronic disease, including CKD and anaemia among Indigenous Australians. A cross-sectional analysis of 594 adult Aboriginal and Torres Strait Islander (TSI) people in good health or with diabetes and markers of CKD. Measures included urine albumin: creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), haemoglobin (Hb) and glycated haemoglobin (HbA1c). Diabetes was defined by medical history, medications or HbA1c≥6.5% or ≥48mmol/mol. Anaemia was defined as Hb<130g/L or <120g/L in males and females respectively. A multivariate regression analysis examining factors independently associated with log-bilirubin was performed. Participants mean (SD) age was 45.1 (14.5) years, and included 62.5% females, 71.7% Aboriginal, 41.1% with diabetes, 16.7% with anaemia, 41% with ACR>3mg/mmol and 18.2% with eGFR<60mL/min/1.73m2. Median bilirubin concentration was lower in females than males (6 v 8μmol/L, p<0.001) and in Aboriginal than TSI participants (6 v 9.5μmol/L, p<0.001). Six factors explained 35% of the variance of log-bilirubin; Hb and cholesterol (both positively related) and ACR, triglycerides, Aboriginal ethnicity and female gender (all inversely related). Serum bilirubin concentrations were positively associated with Hb and total cholesterol, and inversely associated with ACR. Further research to determine reasons explaining lower bilirubin concentrations among Aboriginal compared with TSI participants are needed.

Citation

Clin Biochem . 2017 Dec;50(18):1040-1047. doi: 10.1016/j.clinbiochem.2017.08.011. Epub 2017 Aug 20.

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/28834701/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5198

Subject

ACR

Bilirubin

Cardiovascular risk

Diabetes

Indigenous

eGFR

MESH subject

Adult

Albuminuria

Australia

Bilirubin

Biomarkers

Creatinine

Cross-Sectional Studies

Diabetes Mellitus

Female

Hemoglobins

Humans

Hypertension

Kidney Failure, Chronic

Male

Middle Aged

Renal Insufficiency, Chronic

Risk Factors

Oceanic Ancestry Group

Title

Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Hughes Wagadagam , Jaquelyne Barzi F Hoy WE Jones GRD Rathnayake G Majoni, Sandawana William Thomas, Mark AB Sinha A Cass A MacIsaac RJ O'Dea K Maple-Brown, Louise
Publication Date	2017-12-01
Abstract	Low serum bilirubin concentrations are reported to be strongly associated with cardio-metabolic disease, but this relationship has not been reported among Indigenous Australian people who are known to be at high risk for diabetes and chronic kidney disease (CKD). serum bilirubin will be negatively associated with markers of chronic disease, including CKD and anaemia among Indigenous Australians. A cross-sectional analysis of 594 adult Aboriginal and Torres Strait Islander (TSI) people in good health or with diabetes and markers of CKD. Measures included urine albumin: creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), haemoglobin (Hb) and glycated haemoglobin (HbA1c). Diabetes was defined by medical history, medications or HbA1c≥6.5% or ≥48mmol/mol. Anaemia was defined as Hb<130g/L or <120g/L in males and females respectively. A multivariate regression analysis examining factors independently associated with log-bilirubin was performed. Participants mean (SD) age was 45.1 (14.5) years, and included 62.5% females, 71.7% Aboriginal, 41.1% with diabetes, 16.7% with anaemia, 41% with ACR>3mg/mmol and 18.2% with eGFR<60mL/min/1.73m2. Median bilirubin concentration was lower in females than males (6 v 8μmol/L, p<0.001) and in Aboriginal than TSI participants (6 v 9.5μmol/L, p<0.001). Six factors explained 35% of the variance of log-bilirubin; Hb and cholesterol (both positively related) and ACR, triglycerides, Aboriginal ethnicity and female gender (all inversely related). Serum bilirubin concentrations were positively associated with Hb and total cholesterol, and inversely associated with ACR. Further research to determine reasons explaining lower bilirubin concentrations among Aboriginal compared with TSI participants are needed.
Citation	Clin Biochem . 2017 Dec;50(18):1040-1047. doi: 10.1016/j.clinbiochem.2017.08.011. Epub 2017 Aug 20.
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/28834701/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5198
Subject	ACR Bilirubin Cardiovascular risk Diabetes Indigenous eGFR
MESH subject	Adult Albuminuria Australia Bilirubin Biomarkers Creatinine Cross-Sectional Studies Diabetes Mellitus Female Hemoglobins Humans Hypertension Kidney Failure, Chronic Male Middle Aged Renal Insufficiency, Chronic Risk Factors Oceanic Ancestry Group
Title	Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study.
Type of document	Journal Article
Entity Type	Publication

Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study.

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