Eilertsen, G Ø; Nossent, J C

Author(s)

Eilertsen, G Ø

Nossent, J C

Publication Date

2014-11-01

Abstract

Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal association between serum APRIL (s-APRIL), serum BAFF (s-BAFF) and immunological and clinical findings in SLE patients. A cross-sectional case-control study was performed in 100 SLE patients (87% female, age 49 years, disease duration 12 years). APRIL and BAFF levels were measured by sandwich ELISA, compared with healthy controls and correlated with autoantibody, cytokine (IL-6 and IL-17) and clinical findings through nonparametric and multivariate regression analyses. Both median s-APRIL (478 vs. 0 pg/ml, p = 0.01) and s-BAFF (1720 vs. 0.9 pg/ml, p < 0.001) were higher in SLE patients than controls. Increased s-BAFF was observed in 86% of patients, while s-APRIL was increased only in 17% (p < 0.01). S-APRIL correlated with s-BAFF in controls (p = 0.04), but not in SLE (p = 0.8). Increased s-APRIL was strongly and independently associated with IL-17 activation (p < 0.001), while increased s-BAFF levels were associated with anti-nucleosome antibody presence (p = 0.001). Disease activity and organ damage were associated with s-BAFF but not s-APRIL. While both s-BAFF and s-APRIL levels are elevated in SLE patients, they reflect different immunologic and clinical pathways. The strong association between s-APRIL and IL-17 activation supports a role for Th17 helper cells in B cell activation in SLE.

Citation

Lupus . 2014 Nov;23(13):1383-91. doi: 10.1177/0961203314543914. Epub 2014 Jul 23.

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/25057039/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5575

Subject

B-lymphocyte activating factor

a proliferation-inducing ligand

autoantibodies

cytokines

interleukin-17

systemic lupus erythematosus

MESH subject

Autoantibodies

B-Cell Activating Factor

Case-Control Studies

Cross-Sectional Studies

Female

Humans

Immunologic Factors

Interleukin-17

Lupus Erythematosus, Systemic

Male

Middle Aged

Severity of Illness Index

Tumor Necrosis Factor Ligand Superfamily Member 13

Title

APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Eilertsen, G Ø Nossent, J C
Publication Date	2014-11-01
Abstract	Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal association between serum APRIL (s-APRIL), serum BAFF (s-BAFF) and immunological and clinical findings in SLE patients. A cross-sectional case-control study was performed in 100 SLE patients (87% female, age 49 years, disease duration 12 years). APRIL and BAFF levels were measured by sandwich ELISA, compared with healthy controls and correlated with autoantibody, cytokine (IL-6 and IL-17) and clinical findings through nonparametric and multivariate regression analyses. Both median s-APRIL (478 vs. 0 pg/ml, p = 0.01) and s-BAFF (1720 vs. 0.9 pg/ml, p < 0.001) were higher in SLE patients than controls. Increased s-BAFF was observed in 86% of patients, while s-APRIL was increased only in 17% (p < 0.01). S-APRIL correlated with s-BAFF in controls (p = 0.04), but not in SLE (p = 0.8). Increased s-APRIL was strongly and independently associated with IL-17 activation (p < 0.001), while increased s-BAFF levels were associated with anti-nucleosome antibody presence (p = 0.001). Disease activity and organ damage were associated with s-BAFF but not s-APRIL. While both s-BAFF and s-APRIL levels are elevated in SLE patients, they reflect different immunologic and clinical pathways. The strong association between s-APRIL and IL-17 activation supports a role for Th17 helper cells in B cell activation in SLE.
Citation	Lupus . 2014 Nov;23(13):1383-91. doi: 10.1177/0961203314543914. Epub 2014 Jul 23.
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/25057039/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5575
Subject	B-lymphocyte activating factor a proliferation-inducing ligand autoantibodies cytokines interleukin-17 systemic lupus erythematosus
MESH subject	Autoantibodies B-Cell Activating Factor Case-Control Studies Cross-Sectional Studies Female Humans Immunologic Factors Interleukin-17 Lupus Erythematosus, Systemic Male Middle Aged Severity of Illness Index Tumor Necrosis Factor Ligand Superfamily Member 13
Title	APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus.
Type of document	Journal Article
Entity Type	Publication

APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus.

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