Cheng  E; Longmore D; Barzi F; Barr ELM; Lee I; Whitbread, Cherie; Boyle JA; Oats J; Connors, Christine; McIntyre HD; Kirkwood M; Dempsey Karen; Zhang,  Xiaohua; Thomas, Sujatha; Williams, Desley; Zimmet P; Brown ADH; Shaw JE; Maple-Brown, Louise

Author(s)

Cheng E

Longmore D

Barzi F

Barr ELM

Lee I

Whitbread, Cherie

Boyle JA

Oats J

Connors, Christine

McIntyre HD

Kirkwood M

Dempsey Karen

Zhang, Xiaohua

Thomas, Sujatha

Williams, Desley

Zimmet P

Brown ADH

Shaw JE

Maple-Brown, Louise

Publication Date

2019-10-03

Abstract

To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. Indigenous (n=97) and Europid (n=113) women managed by lifestyle modification were compared to women without hyperglycaemia (n=235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73 weeks), lower birthweight z-score (by 0.26, p=0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), p=0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), p < 0.001] than women without hyperglycaemia CONCLUSION: Women with GDM managed by lifestyle modification had higher induction rates and their offspring had lower birthweight z-scores, with a trend to lower LGA than those without hyperglycaemia in pregnancy. Further studies are indicated to explore reasons for higher induction rates.

Citation

Diabetes research and clinical practice 2019-10-03: 107876

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/31586661/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/7811

Subject

Aboriginal and Torres Strait Island

Gestational diabetes mellitus

hyperglycaemia in pregnancy

induction of labour

lifestyle modification

Title

Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA Study.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Cheng E Longmore D Barzi F Barr ELM Lee I Whitbread, Cherie Boyle JA Oats J Connors, Christine McIntyre HD Kirkwood M Dempsey Karen Zhang, Xiaohua Thomas, Sujatha Williams, Desley Zimmet P Brown ADH Shaw JE Maple-Brown, Louise
Publication Date	2019-10-03
Abstract	To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. Indigenous (n=97) and Europid (n=113) women managed by lifestyle modification were compared to women without hyperglycaemia (n=235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73 weeks), lower birthweight z-score (by 0.26, p=0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), p=0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), p < 0.001] than women without hyperglycaemia CONCLUSION: Women with GDM managed by lifestyle modification had higher induction rates and their offspring had lower birthweight z-scores, with a trend to lower LGA than those without hyperglycaemia in pregnancy. Further studies are indicated to explore reasons for higher induction rates.
Citation	Diabetes research and clinical practice 2019-10-03: 107876
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/31586661/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/7811
Subject	Aboriginal and Torres Strait Island Gestational diabetes mellitus hyperglycaemia in pregnancy induction of labour lifestyle modification
Title	Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA Study.
Type of document	Journal Article
Entity Type	Publication

Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA Study.

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