Self-inflicted injury/self-directed violence is a vast topic that is complex and multi-factorial. Various classification systems exist, and several categories based on the underlying motive(s) are proposed. Self-directed violence is seen in diverse clinical fields. The medico-legal importance in the assessment of injuries is to assist in establishing the underlying manner in which they were sustained. To assist in the determination of self-inflicted injury, “typical” injury patterns have been described; however, “atypical” injuries does not preclude such a diagnosis. A comprehensive history, examination, and ancillary investigations are required in the assessment of self-inflicted injuries.