Roberts, L J; Huffam, Sarah; Walton, S F; Currie, Bart

Author(s)

Roberts, L J

Huffam, Sarah

Walton, S F

Currie, Bart

Publication Date

2005-06-01

Abstract

To describe the clinical and immunological features of crusted scabies in a prospectively ascertained cohort of 78 patients. All patients requiring inpatient treatment for crusted scabies in the 'top end' of the northern territory of Australia over a 10 year period were prospectively identified. Demographics, risk factors, and immunological parameters were retrospectively compiled from their medical records and pathology databases. More than half the patients with crusted scabies had identifiable immunosuppressive risk factors. Eosinophilia and elevated IgE levels occurred in 58% and 96% of patients, respectively, with median IgE levels 17 times the upper limit of normal. Seventeen percent had a history of leprosy but 42% had no identifiable risk factors. There was a decrease in mortality after the introduction of a treatment protocol consisting of multiple doses of ivermectin combined with topical scabicides and keratolytic therapy. Crusted scabies often occurs in patients with identifiable immunosuppressive risk factors. In patients without such risk factors, it is possible that the crusted response to infection results from a tendency to preferentially mount a Th2 response. The treatment regime described was associated with a reduction in mortality. This is the largest reported case series of crusted scabies.

Affiliation

Infectious Diseases Unit, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin, Northern Territory, Australia..

Citation

J Infect . 2005 Jun;50(5):375-81. doi: 10.1016/j.jinf.2004.08.033.

ISSN

0163-4453

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/15907543/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5809

MESH subject

Administration, Oral

Administration, Topical

Adolescent

Adult

Aged

Antiparasitic Agents

Australia

Drug Therapy, Combination

Humans

Immunoglobulin E

Infant, Newborn

Ivermectin

Keratolytic Agents

Leprosy

Middle Aged

Risk Factors

Scabies

Eosinophilia

Immunocompromised Host

Review Literature as Topic

Title

Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Roberts, L J Huffam, Sarah Walton, S F Currie, Bart
Publication Date	2005-06-01
Abstract	To describe the clinical and immunological features of crusted scabies in a prospectively ascertained cohort of 78 patients. All patients requiring inpatient treatment for crusted scabies in the 'top end' of the northern territory of Australia over a 10 year period were prospectively identified. Demographics, risk factors, and immunological parameters were retrospectively compiled from their medical records and pathology databases. More than half the patients with crusted scabies had identifiable immunosuppressive risk factors. Eosinophilia and elevated IgE levels occurred in 58% and 96% of patients, respectively, with median IgE levels 17 times the upper limit of normal. Seventeen percent had a history of leprosy but 42% had no identifiable risk factors. There was a decrease in mortality after the introduction of a treatment protocol consisting of multiple doses of ivermectin combined with topical scabicides and keratolytic therapy. Crusted scabies often occurs in patients with identifiable immunosuppressive risk factors. In patients without such risk factors, it is possible that the crusted response to infection results from a tendency to preferentially mount a Th2 response. The treatment regime described was associated with a reduction in mortality. This is the largest reported case series of crusted scabies.
Affiliation	Infectious Diseases Unit, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Citation	J Infect . 2005 Jun;50(5):375-81. doi: 10.1016/j.jinf.2004.08.033.
ISSN	0163-4453
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/15907543/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5809
MESH subject	Administration, Oral Administration, Topical Adolescent Adult Aged Antiparasitic Agents Australia Drug Therapy, Combination Humans Immunoglobulin E Infant, Newborn Ivermectin Keratolytic Agents Leprosy Middle Aged Risk Factors Scabies Eosinophilia Immunocompromised Host Review Literature as Topic
Title	Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature.
Type of document	Journal Article
Entity Type	Publication

Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature.

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