Proudmore, Kate

Swe, Ma Nu Nu

Leitch, May

Clayfield, Kim

Hennessy, Jann

Baird, Robert

2023-09-21

Group B streptococcus (GBS) is a significant cause of perinatal morbidity and mortality; prophylactic antibiotics in the obstetric population can mitigate the risk of neonatal infection. The antibiotic of choice is penicillin; however, in women who have a penicillin hypersensitivity, clindamycin is the preferred agent. Worldwide resistance to clindamycin is rising in GBS isolates. In the Top End of the Northern Territory of Australia, we reviewed 113 GBS isolates in 2023. These GBS isolates revealed a 30% resistance to clindamycin. This rate has considerably increased since the Australia-wide survey published in 2011 where GBS resistance to clindamycin was quoted at 4.2%. As a result of this study, we are advocating for a change in practice in patients with known GBS resistance with penicillin hypersensitivity.

Advanced Trainee Infectious Diseases and Acute and General Care Medicine; Territory Pathology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.;Department of Microbiology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.. kate.proudmore@nt.gov.au.

Territory Pathology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.; Department of Microbiology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.. none@example.com.

Territory Pathology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.; Clinical Microbiologist and Director of Pathology, Territory Pathology, Royal Darwin Hospital, Rocklands Drive TIWI NT 0810 Australia.. none@example.com.

Commun Dis Intell (2018). 2023 Sep 21;47. doi: 10.33321/cdi.2023.47.52.

https://pubmed.ncbi.nlm.nih.gov/37817335/?otool=iaurydwlib

https://hdl.handle.net/10137/12563

47

Humans

*Anti-Bacterial Agents/pharmacology/therapeutic use

*Clindamycin/pharmacology/therapeutic use

Northern Territory/epidemiology

*Streptococcus agalactiae/drug effects

*Streptococcal Infections/drug therapy/epidemiology/microbiology

*Drug Resistance, Bacterial

Group B streptococcus in the Northern Territory in 2023: clindamycin down but not out.

Journal Article

Publication