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Acronym
RADAR
Project Title
A randomised phase III trial with a PET response adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin Lymphoma
Principal Investigator
Start Date
November 7, 2022
Investigators
Rajah, Karthik
Project Web Site
Keywords
Hodgkin Lyphoma
Project Type
Interventional/Clinical trials research
Location
Region
Keywords

Hodgkin Lyphoma

Description
SOC for newly diagnosed and untreated participants with early-stage Hodgkin Lymphoma is a combination of 4 chemo drugs (ABVD), sometimes followed by radiotherapy. This trial investigates if swapping one of the drugs in ABVD for brentuximab vedotin improves SOC for early-stage HL. This regime is called A2VD. Advanced stage HL patients, treated with A2VD slightly reduced the risk of lymphoma coming back (relapsing) compared with ABVD.

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