Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/7508
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Title: Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study.
Authors: Longmore, Danielle K
Barr, Elizabeth L M
Lee, I-Lynn
Barzi, Federica
Kirkwood, Marie
Whitbread, Cherie
Hampton, Vanya
Graham, Sian
Van Dokkum, Paula
Connors, Christine
Boyle, Jacqueline A
Catalano, Patrick
Brown, Alex D H
O'Dea, Kerin
Oats, Jeremy
McIntyre, H David
Shaw, Jonathan E
Maple-Brown, Louise J
Citation: Pediatric obesity 2019-04; 14(4): e12490
Abstract: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/30650263
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/30650263
Journal title: Pediatric obesity
Publication Date: 2019-04
Type: Journal Article
URI: https://hdl.handle.net/10137/7508
DOI: 10.1111/ijpo.12490
metadata.dc.identifier.orcid: https://orcid.org/0000-0002-6232-8947
https://orcid.org/0000-0003-4284-1716
Appears in Collections:(a) NT Health Research Collection

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