Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/7198
Title: Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.
Authors: Turpin J
Yurick D
Khoury G
Pham H
Locarnini S
Melamed A
Witkover A
Wilson K
Purcell D
Bangham CRM
Einsiedel LJ
Citation: The Journal of infectious diseases 2018-10-11
Abstract: The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1-associated malignant disease.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//30307560
Journal title: The Journal of infectious diseases
Publication Date: 2018-10-11
Type: Journal Article
URI: https://hdl.handle.net/10137/7198
DOI: 10.1093/infdis/jiy546
Appears in Collections:(a) NT Health Research Collection

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