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Title: Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.
Authors: Turpin, Jocelyn
Yurick, David
Khoury, Georges
Pham, Hai
Locarnini, Stephen
Melamed, Anat
Witkover, Aviva
Wilson, Kim
Purcell, Damian
Bangham, Charles R M
Einsiedel, Lloyd
Citation: The Journal of infectious diseases 2018-10-11
Abstract: The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1-associated malignant disease.
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Journal title: The Journal of infectious diseases
Publication Date: 2018-10-11
Type: Journal Article
DOI: 10.1093/infdis/jiy546
Appears in Collections:(a) NT Health Research Collection

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