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Title: Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children.
Authors: Smith-Vaughan, Heidi C
Binks, Michael J
Beissbarth, Jemima
Chang, Anne B
McCallum, Gabrielle B
Mackay, Ian M
Morris, Peter S
Marsh, Robyn L
Torzillo, Paul J
Wurzel, Danielle F
Grimwood, Keith
Nosworthy, Elizabeth
Gaydon, Jane E
Leach, Amanda J
MacHunter, Barbara
Chatfield, Mark D
Sloots, Theo P
Cheng, Allen C
Citation: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018-09; 37(9): 1785-1794
Abstract: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR = 3.08, 95% CI 1.22-7.76, p = 0.017), but this association was not significant in cases versus different child controls (15 vs 10%; OR = 1.93, 95% CI 0.97-3.87 (p = 0.063). No other microbes were more prevalent in cases compared to controls. Streptococcus pneumoniae (74%), Haemophilus influenzae (75%) and Moraxella catarrhalis (88%) were commonly identified across all swabs. In a pediatric population with a high detection rate of nasopharyngeal microbes, HAdV was the only pathogen detected in the period before illness presentation that was significantly associated with ALRI onset. Detection of other potential ALRI pathogens was similar between cases and controls.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/29959609
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/29959609
Journal title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Publication Date: 2018-09
Type: Journal Article
URI: https://hdl.handle.net/10137/7100
DOI: 10.1007/s10096-018-3314-7
Appears in Collections:(a) NT Health Research Collection

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