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Title: Ultrastructural identification of a proximal tubulopathy without crystals in a relapsed multiple myeloma patient.
Authors: Brealey, John K
Tran, Yung
Ninnes, Ruth
Abeyaratne, Asanga
Citation: Ultrastructural pathology 2018-09-25: 1-6
Abstract: A multiple myeloma patient, who had been treated with a hematopoietic stem cell transplant, underwent a renal biopsy for investigation of a possible relapse of disease as indicated by increased serum creatinine and positive urinary Bence-Jones protein containing increased kappa light chain. Paraprotein-related renal disease was not evident by light microscopy or immunofluorescence microscopy however electron microscopy demonstrated a proximal tubulopathy with intracytoplasmic non-crystalline inclusions. The ultrastructural findings suggested possible end-organ involvement by the disease and follow-up studies subsequently revealed a relapsed multiple myeloma in the patient. The case exemplifies the usefulness of electron microscopy in detecting paraproteins that, in some instances, may be difficult to demonstrate by other techniques.
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Journal title: Ultrastructural pathology
Publication Date: 2018-09-25
Type: Journal Article
DOI: 10.1080/01913123.2018.1526243
Appears in Collections:(a) NT Health Research Collection

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