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Title: Ultrastructural identification of a proximal tubulopathy without crystals in a relapsed multiple myeloma patient.
Authors: Brealey, John K
Tran, Yung
Ninnes, Ruth
Abeyaratne, Asanga
Citation: Ultrastructural pathology 2018-09-25: 1-6
Abstract: A multiple myeloma patient, who had been treated with a hematopoietic stem cell transplant, underwent a renal biopsy for investigation of a possible relapse of disease as indicated by increased serum creatinine and positive urinary Bence-Jones protein containing increased kappa light chain. Paraprotein-related renal disease was not evident by light microscopy or immunofluorescence microscopy however electron microscopy demonstrated a proximal tubulopathy with intracytoplasmic non-crystalline inclusions. The ultrastructural findings suggested possible end-organ involvement by the disease and follow-up studies subsequently revealed a relapsed multiple myeloma in the patient. The case exemplifies the usefulness of electron microscopy in detecting paraproteins that, in some instances, may be difficult to demonstrate by other techniques.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/30252563
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/30252563
Journal title: Ultrastructural pathology
Publication Date: 2018-09-25
Type: Journal Article
URI: https://hdl.handle.net/10137/7081
DOI: 10.1080/01913123.2018.1526243
Appears in Collections:(a) NT Health Research Collection

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