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https://hdl.handle.net/10137/6840
Title: | Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature. |
Authors: | Currie BJ Fisher DA Howard DM Burrow JN Lo D Selva-Nayagam S Anstey NM Huffam SE Snelling PL Marks PJ Stephens DP Lum GD Jacups SP Krause VL |
Citation: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000-10; 31(4): 981-6 |
Abstract: | In a prospective study of melioidosis in northern Australia, 252 cases were found over 10 years. Of these, 46% were bacteremic, and 49 (19%) patients died. Despite administration of ceftazidime or carbapenems, mortality was 86% (43 of 50 patients) among those with septic shock. Pneumonia accounted for 127 presentations (50%) and genitourinary infections for 37 (15%), with 35 men (18%) having prostatic abscesses. Other presentations included skin abscesses (32 patients; 13%), osteomyelitis and/or septic arthritis (9; 4%), soft tissue abscesses (10; 4%), and encephalomyelitis (10; 4%). Risk factors included diabetes (37%), excessive alcohol intake (39%), chronic lung disease (27%), chronic renal disease (10%), and consumption of kava (8%). Only 1 death occurred among the 51 patients (20%) with no risk factors (relative risk, 0.08; 95% confidence interval, 0.01-0.58). Intensive therapy with ceftazidime or carbapenems, followed by at least 3 months of eradication therapy with trimethoprim-sulfamethoxazole, was associated with decreased mortality. Strategies are needed to decrease the high mortality with melioidosis septic shock. Preliminary data on granulocyte colony-stimulating factor therapy are very encouraging. |
Click to open PubMed article: | https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//11049780 |
Journal title: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Publication Date: | 2000-10 |
ISSN: | 1058-4838 |
Type: | Journal Article Review |
URI: | https://hdl.handle.net/10137/6840 |
DOI: | 10.1086/318116 |
Appears in Collections: | (a) NT Health Research Collection |
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