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dc.contributor.authorLeach AJen
dc.contributor.authorMorris PSen
dc.contributor.authorMcCallum GBen
dc.contributor.authorWilson CAen
dc.contributor.authorStubbs Len
dc.contributor.authorBeissbarth Jen
dc.contributor.authorJacups Sen
dc.contributor.authorHare Ken
dc.contributor.authorSmith-Vaughan HCen
dc.identifier.citationBMC infectious diseases 2009-08-04; 9: 121en
dc.description.abstractIn Australia in June 2001, a unique pneumococcal vaccine schedule commenced for Indigenous infants; seven-valent pneumococcal conjugate vaccine (7PCV) given at 2, 4, and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months of age. This study presents carriage serotypes following this schedule. We conducted cross sectional surveys of pneumococcal carriage in Aboriginal children 0 to 6 years of age living in remote Aboriginal communities (RACs) in 2003 and 2005. Nasal secretions were collected and processed according to published methods. 902 children (mean age 25 months) living in 29 communities in 2003 and 818 children (mean age 35 months) in 17 communities in 2005 were enrolled. 87% children in 2003 and 96% in 2005 had received two or more doses of 7PCV. From 2003 to 2005, pneumococcal carriage was reduced from 82% to 76% and reductions were apparent in all age groups; 7PCV-type carriage was reduced from 11% to 8%, and 23PPV-non-7PCV-type carriage from 31% to 25% respectively. Thus non-23PPV-type carriage increased from 57% to 67%. All these changes were statistically significant, as were changes for some specific serotypes. Shifts could not be attributed to vaccination alone. The top 10 of 40 serotypes identified were (in descending order) 16F, 19A, 11A, 6C, 23B, 19F, 6A, 35B, 6B, 10A and 35B. Carriage of penicillin non-susceptible (MIC > or = 0.12 microg/mL) strains (15% overall) was detected in serotypes (descending order) 19A, 19F, 6B, 16F, 11A, 9V, 23B, and in 4 additional serotypes. Carriage of azithromycin resistant (MIC > or = 2 microg/mL) strains (5% overall), was detected in serotypes (descending order) 23B, 17F, 9N, 6B, 6A, 11A, 23F, and in 10 additional serotypes including 6C. Pneumococcal carriage remains high (approximately80%) in this vaccinated population. Uptake of both pneumococcal vaccines increased, and carriage was reduced between 2003 and 2005. Predominant serotypes in combined years were 16F, 19A, 11A, 6C and 23B. Antimicrobial non-susceptibility was detected in these and 17 additional serotypes. Shifts in serotype-specific carriage suggest a need more research to clarify the association between pneumococcal vaccination and carriage at the serotype level.en
dc.titleEmerging pneumococcal carriage serotypes in a high-risk population receiving universal 7-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine since 2001.en
dc.typeJournal Articleen
dc.identifier.journaltitleBMC infectious diseasesen
dc.subject.meshCarrier Stateen
dc.subject.meshChild, Preschoolen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshDrug Resistance, Bacterialen
dc.subject.meshHeptavalent Pneumococcal Conjugate Vaccineen
dc.subject.meshImmunization Programsen
dc.subject.meshPneumococcal Vaccinesen
dc.subject.meshStreptococcus pneumoniaeen
dc.identifier.affiliationMenzies School of Health Research, John Mathews Building (Bldg58), Royal Darwin Hospital, Rocklands Drive, Tiwi, Northern Territory, Australia.
Appears in Collections:(a) NT Health Research Collection

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