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dc.contributor.authorBowen ACen
dc.contributor.authorCarapetis Jen
dc.identifier.citationAdvances in experimental medicine and biology 2011; 697: 91-106en
dc.description.abstractInfection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.en
dc.titleAdvances in the diagnosis and management of central venous access device infections in children.en
dc.typeJournal Articleen
dc.identifier.journaltitleAdvances in experimental medicine and biologyen
dc.subject.meshInfection Controlen
dc.subject.meshBacterial Infectionsen
dc.subject.meshCatheterization, Central Venousen
dc.identifier.affiliationPaediatric Infectious Diseases, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..en
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