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Title: Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.
Authors: Salwati, Ervi
Minigo, Gabriela
Woodberry, Tonia
Piera, Kim A
de Silva, Harini D
Kenangalem, Enny
Tjitra, Emiliana
Coppel, Ross L
Price, Ric N
Anstey, Nicholas M
Plebanski, Magdalena
Citation: The Journal of infectious diseases 2011-04-15; 203(8): 1192-1199
Abstract: Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. Lymphoproliferation and IFN--γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n=34), and vivax malaria (n=12) or asymptomatic residents (n=10) of Papua, Indonesia. Responses were reassessed 7-28 days following treatment. The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γ-secreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/21451007
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/21451007
Journal title: The Journal of infectious diseases
Publication Date: 2011-04-15
Type: Journal Article
Research Support, Non-U.S. Gov't
URI: https://hdl.handle.net/10137/5701
DOI: 10.1093/infdis/jiq166
Appears in Collections:(a) NT Health Research Collection

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