Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5611
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dc.contributor.authorMaple-Brown LJen
dc.contributor.authorEkinci EIen
dc.contributor.authorHughes JTen
dc.contributor.authorChatfield Men
dc.contributor.authorLawton PDen
dc.contributor.authorJones GRDen
dc.contributor.authorEllis AGen
dc.contributor.authorSinha Aen
dc.contributor.authorCass Aen
dc.contributor.authorHoy WEen
dc.contributor.authorO'Dea Ken
dc.contributor.authorJerums Gen
dc.contributor.authorMacIsaac RJen
dc.date2014en
dc.date.accessioned2018-05-15T23:01:20Zen
dc.date.available2018-05-15T23:01:20Zen
dc.date.issued2014-07en
dc.identifier.citationDiabetic medicine : a journal of the British Diabetic Association 2014-07; 31(7): 829-38en
dc.identifier.urihttps://hdl.handle.net/10137/5611en
dc.description.abstractIt has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high incidence of diabetes and end-stage kidney disease in Indigenous Australians, accurate estimation of glomerular filtration rate is vital in early detection of kidney disease. We aimed to assess the performance of the Chronic Kidney Disease Epidemiology Collaboration, Modification of Diet in Renal Disease and Cockcroft-Gault formulas in Indigenous Australians with and without diabetes. Indigenous Australians with (n = 224) or without (n = 340) Type 2 diabetes had a reference glomerular filtration rate measure using plasma disappearance of iohexol (measured glomerular filtration rate) over 4 h. Serum creatinine was measured by an enzymatic method. Performance was assessed by bias (measured glomerular filtration rate - estimated glomerular filtration rate) and accuracy (percentage of estimated glomerular filtration rate within 30% of measured glomerular filtration rate). The median measured glomerular filtration rate (interquartile range) in participants with or without diabetes was 97 (68-119) and 108 (90-122) ml min(-1)  1.73 m(-2) , respectively. The Chronic Kidney Disease Epidemiology Collaboration formula had smaller bias and greater accuracy than the Modification of Diet in Renal Disease and Cockcroft-Gault formulas overall, for participants both with and without diabetes. However, for estimated glomerular filtration rate > 90 ml min(-1)  1.73 m(-2) , the Chronic Kidney Disease Epidemiology Collaboration formula had greater bias in participants with diabetes, underestimating measured glomerular filtration rate by 7.4 vs. 1.0 ml min(-1)  1.73 m(-2) in those without diabetes. The Chronic Kidney Disease Epidemiology Collaboration formula was less accurate across the whole range of estimated glomerular filtration rates in participants with vs. those without diabetes (87.1% vs. 93.3%). The Chronic Kidney Disease Epidemiology Collaboration formula outperforms the Modification of Diet in Renal Disease and Cockcroft-Gault formulas overall in Indigenous Australians with and without diabetes. However, the Chronic Kidney Disease Epidemiology Collaboration formula has greater bias in people with diabetes compared with those without diabetes, especially in those with normal renal function.en
dc.language.isoengen
dc.titlePerformance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: the eGFR Study.en
dc.typeComparative Studyen
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetic medicine : a journal of the British Diabetic Associationen
dc.identifier.doi10.1111/dme.12426en
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//24598003en
dc.subject.meshAustraliaen
dc.subject.meshCreatinineen
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshDiet, Diabeticen
dc.subject.meshEarly Diagnosisen
dc.subject.meshFemaleen
dc.subject.meshGlomerular Filtration Rateen
dc.subject.meshHealth Services, Indigenousen
dc.subject.meshHumansen
dc.subject.meshKidney Function Testsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPredictive Value of Testsen
dc.subject.meshRenal Insufficiency, Chronicen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshIohexolen
dc.subject.meshOceanic Ancestry Groupen
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University; Division of Medicine, Royal Darwin Hospital, NT..en
Appears in Collections:(a) NT Health Research Collection

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