Warrilow D

Watterson D

Hall RA

Davis SS

Weir R

Kurucz, Nina

Whelan PI

Allcock R

Hall MS

O'Brien A

Hobson PJ

2014-03-01

Here we describe Casuarina virus (CASV), a new virus in the family Mesoniviridae. This is the first report of a mesonivirus in Australia, which extends the geographical range of this virus family to 3 continents. The virus was isolated in 2010 from Coquillettidia xanthogaster mosquitoes during surveillance in the suburbs of Darwin, the capital of the Northern Territory. Cryo-electron microscopy of the CASV virions revealed spherical particles of 65 nm in size with large club-shaped projections of approximately 15 nm in length. The new virus was most closely related to Alphamesonivirus 1, the only currently recognized species in the family. In 2013 a further 5 putative new mesonivirus species were described: Hana, Méno, Nsé, Moumo and Dak Nong viruses. The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses (Jones-Taylor-Thornton distance of 0.151 and 0.224, respectively), along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species.

Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Archerfield, Queensland, Australia..

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia..

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia..

Berrimah Veterinary Labs, Department of Primary Industries and Fisheries, Darwin, Northern Territory, Australia..

Berrimah Veterinary Labs, Department of Primary Industries and Fisheries, Darwin, Northern Territory, Australia..

Centre for Disease Control, Health Protection Division, Northern Territory Department of Health, Darwin, Northern Territory, Australia..

Centre for Disease Control, Health Protection Division, Northern Territory Department of Health, Darwin, Northern Territory, Australia..

LotteryWest State Biomedical Facility, Genomics, School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia; Department of Clinical Immunology, Pathwest Laboratory Medicine Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia..

Public Health Virology Laboratory, Forensic and Scientific Services, Department of Health, Archerfield, Queensland, Australia..

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia..

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia..

PLoS One . 2014 Mar 26;9(3):e91103. doi: 10.1371/journal.pone.0091103. eCollection 2014.

https://pubmed.ncbi.nlm.nih.gov/24670468/?otool=iaurydwlib

https://hdl.handle.net/10137/5604

Animals

Cell Line

Computer Simulation

Cryoelectron Microscopy

Culicidae

Nidovirales

Northern Territory

Phylogeny

Protein Structure, Tertiary

RNA Replicase

Sequence Homology, Amino Acid

Species Specificity

Viral Proteins

Virion

Virus Replication

A new species of mesonivirus from the Northern Territory, Australia.

Journal Article

Publication