Please use this identifier to cite or link to this item:
Email to ask for this document in a different format
Title: Unprecedented Melioidosis Cases in Northern Australia Caused by an Asian Burkholderia pseudomallei Strain Identified by Using Large-Scale Comparative Genomics.
Authors: Price, Erin P
Sarovich, Derek S
Smith, Emma J
MacHunter, Barbara
Harrington, Glenda
Theobald, Vanessa
Hall, Carina M
Hornstra, Heidie M
McRobb, Evan
Podin, Yuwana
Mayo, Mark
Sahl, Jason W
Wagner, David M
Keim, Paul
Kaestli, Mirjam
Currie, Bart J
Citation: Applied and environmental microbiology 2016; 82(3): 954-63
Abstract: Melioidosis is a disease of humans and animals that is caused by the saprophytic bacterium Burkholderia pseudomallei. Once thought to be confined to certain locations, the known presence of B. pseudomallei is expanding as more regions of endemicity are uncovered. There is no vaccine for melioidosis, and even with antibiotic administration, the mortality rate is as high as 40% in some regions that are endemic for the infection. Despite high levels of recombination, phylogenetic reconstruction of B. pseudomallei populations using whole-genome sequencing (WGS) has revealed surprisingly robust biogeographic separation between isolates from Australia and Asia. To date, there have been no confirmed autochthonous melioidosis cases in Australia caused by an Asian isolate; likewise, no autochthonous cases in Asia have been identified as Australian in origin. Here, we used comparative genomic analysis of 455 B. pseudomallei genomes to confirm the unprecedented presence of an Asian clone, sequence type 562 (ST-562), in Darwin, northern Australia. First observed in Darwin in 2005, the incidence of melioidosis cases attributable to ST-562 infection has steadily risen, and it is now a common strain in Darwin. Intriguingly, the Australian ST-562 appears to be geographically restricted to a single locale and is genetically less diverse than other common STs from this region, indicating a recent introduction of this clone into northern Australia. Detailed genomic and epidemiological investigations of new clinical and environmental B. pseudomallei isolates in the Darwin region and ST-562 isolates from Asia will be critical for understanding the origin, distribution, and dissemination of this emerging clone in northern Australia.
Click to open PubMed article:
Click to open Pubmed Article:
Journal title: Applied and environmental microbiology
Publication Date: 2016
Type: Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
DOI: 10.1128/AEM.03013-15
metadata.dc.identifier.orcid: 0000-0002-1079-4882
Appears in Collections:(a) NT Health Research Collection

Files in This Item:
There are no files associated with this item.

Items in ePublications are protected by copyright, with all rights reserved, unless otherwise indicated.