Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5360
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dc.contributor.authorRamanathan Gen
dc.contributor.authorAbeyaratne Aen
dc.contributor.authorSundaram Men
dc.contributor.authorFernandes DKen
dc.contributor.authorPawar Ben
dc.contributor.authorPerry GJen
dc.contributor.authorSajiv Cen
dc.contributor.authorMajoni SWen
dc.date.accessioned2018-05-15T23:00:44Zen
dc.date.available2018-05-15T23:00:44Zen
dc.date.issued2017-05en
dc.identifier.citationNephrology (Carlton, Vic.) 2017-05; 22(5): 403-411en
dc.identifier.urihttps://hdl.handle.net/10137/5360en
dc.description.abstractAcute postinfectious glomerulonephritis is common in indigenous communities in the Northern Territory, Australia. It is a major risk factor for the high prevalence of chronic kidney disease. We aimed to analyse the clinical presentation, pathological spectra, treatment and outcomes of biopsy-proven acute postinfectious glomerulonephritis in the Northern Territory. We performed a retrospective cohort analysis of all adult patients (≥18 years) who were diagnosed with acute postinfectious glomerulonephritis on native renal biopsies from 01/01/2004 to 31/05/2014. The outcome measure was end-stage renal disease requiring long-term dialysis. Forty-three of 340 patients who had renal biopsies had acute postinfectious glomerulonephritis. Most were Aboriginals (88.4%). They had co-morbidities; diabetes mellitus (60.5%), hypertension (60.5%) and smoking (56.4%). Forty-nine per cent had multiple pathologies on biopsy. Predominant histological pattern was diffuse proliferative glomerulonephritis (72%). Main sites of infections were skin (47.6%) and upper respiratory tract infection (26.2%) with streptococcus and staphylococcus as predominant organisms. Fifty per cent of patients developed end-stage renal disease. On multivariable logistic regression analysis, those on dialysis had higher baseline creatinine (P = 0.003), higher albumin/creatinine ratio at presentation (P = 0.023), higher serum creatinine at presentation (P = 0.02) and lower estimated glomerular filtration rate at presentation (P = 0.012). Overall, most patients had pre-existing pathology with superimposed acute postinfectious glomerulonephritis that led to poor outcomes in our cohort.en
dc.language.isoengen
dc.subjectAboriginesen
dc.subjectAustraliaen
dc.subjectend-stage renal failureen
dc.subjectglomerulonephritisen
dc.subjectinfectionen
dc.titleAnalysis of clinical presentation, pathological spectra, treatment and outcomes of biopsy-proven acute postinfectious glomerulonephritis in adult indigenous people of the Northern Territory of Australia.en
dc.typeJournal Articleen
dc.typeMulticenter Studyen
dc.identifier.journaltitleNephrology (Carlton, Vic.)en
dc.identifier.doi10.1111/nep.12797en
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//27062647en
dc.subject.meshAcute Diseaseen
dc.subject.meshAdulten
dc.subject.meshBiopsyen
dc.subject.meshCommunicable Diseasesen
dc.subject.meshComorbidityen
dc.subject.meshDisease Progressionen
dc.subject.meshFemaleen
dc.subject.meshFluorescent Antibody Techniqueen
dc.subject.meshGlomerulonephritisen
dc.subject.meshHumansen
dc.subject.meshKidneyen
dc.subject.meshKidney Failure, Chronicen
dc.subject.meshMaleen
dc.subject.meshMicroscopy, Electronen
dc.subject.meshMiddle Ageden
dc.subject.meshNorthern Territoryen
dc.subject.meshRenal Dialysisen
dc.subject.meshRetrospective Studiesen
dc.subject.meshRisk Factorsen
dc.subject.meshTime Factorsen
dc.subject.meshTreatment Outcomeen
dc.subject.meshOceanic Ancestry Groupen
dc.identifier.affiliationDepartment of Nephrology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.. Department of Nephrology, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Royal Perth Hospital, Perth, Western Australia, Australia.. School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.. Northern Territory Medical Programme, School of Medicine, Flinders University, Darwin, Northern Territory, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.. Northern Territory Medical Programme, School of Medicine, Flinders University, Darwin, Northern Territory, Australia..en
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