Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5344
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Title: Chronic Recurrent Multifocal Q Fever Osteomyelitis in Children: An Emerging Clinical Challenge.
Authors: Francis, Joshua R
Robson, Jennifer
Wong, David
Walsh, Mark
Astori, Ivan
Gill, David
Nourse, Clare
Citation: The Pediatric infectious disease journal 2016; 35(9): 972-6
Abstract: Clinical disease caused by Coxiella burnetii occurs infrequently in children. Chronic Q fever is particularly uncommon and endocarditis is rarely seen. A small number of cases of Q fever osteomyelitis have been described but the pathophysiology is not well understood and optimal treatment is unknown. We describe a series of cases of chronic recurrent multifocal Q fever osteomyelitis cases diagnosed in children from a single region in Australia. Between 2011 and 2014, 9 cases of chronic recurrent multifocal Q fever osteomyelitis were diagnosed based on clinical findings, suggestive serology and detection of C. burnetii DNA by polymerase chain reaction testing of biopsy samples (8/9). All required surgical management; antibiotic and adjuvant therapies did not appear to be consistently effective and 2 cases had clinical resolution in the absence of directed antimicrobial therapy. Chronic recurrent multifocal osteomyelitis is a rare manifestation of chronic Q fever infection in children. The pathophysiology of this condition is poorly understood, and effective treatment options have not been established.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/27294309
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/27294309
Journal title: The Pediatric infectious disease journal
Publication Date: 2016
Type: Journal Article
URI: https://hdl.handle.net/10137/5344
DOI: 10.1097/INF.0000000000001211
Appears in Collections:(a) NT Health Research Collection

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