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dc.contributor.authorMcMullan, Brendan J-
dc.contributor.authorAndresen, David-
dc.contributor.authorBlyth, Christopher C-
dc.contributor.authorAvent, Minyon L-
dc.contributor.authorBowen, Asha C-
dc.contributor.authorBritton, Philip N-
dc.contributor.authorClark, Julia E-
dc.contributor.authorCooper, Celia M-
dc.contributor.authorCurtis, Nigel-
dc.contributor.authorGoeman, Emma-
dc.contributor.authorHazelton, Briony-
dc.contributor.authorHaeusler, Gabrielle M-
dc.contributor.authorKhatami, Ameneh-
dc.contributor.authorNewcombe, James P-
dc.contributor.authorOsowicki, Joshua-
dc.contributor.authorPalasanthiran, Pamela-
dc.contributor.authorStarr, Mike-
dc.contributor.authorLai, Tony-
dc.contributor.authorNourse, Clare-
dc.contributor.authorFrancis, Joshua R-
dc.contributor.authorIsaacs, David-
dc.contributor.authorBryant, Penelope A-
dc.date2016-
dc.date.accessioned2018-05-15T23:00:42Z-
dc.date.available2018-05-15T23:00:42Z-
dc.date.issued2016-
dc.identifier.citationThe Lancet. Infectious diseases 2016; 16(8): e139-52-
dc.identifier.urihttps://hdl.handle.net/10137/5341-
dc.description.abstractFew studies are available to inform duration of intravenous antibiotics for children and when it is safe and appropriate to switch to oral antibiotics. We have systematically reviewed antibiotic duration and timing of intravenous to oral switch for 36 paediatric infectious diseases and developed evidence-graded recommendations on the basis of the review, guidelines, and expert consensus. We searched databases and obtained information from references identified and relevant guidelines. All eligible studies were assessed for quality. 4090 articles were identified and 170 studies were included. Evidence relating antibiotic duration to outcomes in children for some infections was supported by meta-analyses or randomised controlled trials; in other infections data were from retrospective series only. Criteria for intravenous to oral switch commonly included defervescence and clinical improvement with or without improvement in laboratory markers. Evidence suggests that intravenous to oral switch can occur earlier than previously recommended for some infections. We have synthesised recommendations for antibiotic duration and intravenous to oral switch to support clinical decision making and prospective research.-
dc.description.provenanceMade available in DSpace on 2018-05-15T23:00:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.language.isoeng-
dc.titleAntibiotic duration and timing of the switch from intravenous to oral route for bacterial infections in children: systematic review and guidelines.-
dc.typeJournal Article-
dc.typeReview-
dc.identifier.journaltitleThe Lancet. Infectious diseases-
dc.identifier.doi10.1016/S1473-3099(16)30024-X-
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/27321363-
dc.subject.meshAnti-Bacterial Agents-
dc.subject.meshBacterial Infections-
dc.subject.meshHumans-
dc.subject.meshPediatrics-
dc.subject.meshAdministration, Intravenous-
dc.subject.meshAdministration, Oral-
dc.identifier.affiliationDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, University of New South Wales, NSW, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases, Immunology, and HIV Medicine, St Vincent's Hospital, Darlinghurst, NSW, Australia; Sydney Medical School, University of Sydney, NSW, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases, Princess Margaret Hospital for Children, Subiaco, WA, Australia; School of Paediatrics and Child Health, University of Western Australia, WA, Australia; PathWest Laboratory Medicine, WA, Australia; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, WA, Australia..-
dc.identifier.affiliationThe University of Queensland, UQ Centre for Clinical Research and School of Public Health, Herston, QLD, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases, Princess Margaret Hospital for Children, Subiaco, WA, Australia; School of Paediatrics and Child Health, University of Western Australia, WA, Australia; Menzies School of Health Research, Darwin, NT, Australia; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, WA, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases & Microbiology, Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, University of Sydney, Sydney, NSW, Australia..-
dc.identifier.affiliationInfection Management and Prevention Service, Lady Cilento Children's Hospital, South Brisbane, QLD, Australia; School of Medicine, University of Queensland, Brisbane, QLD, Australia..-
dc.identifier.affiliationDepartment of Microbiology and Infectious Diseases, SA Pathology, Women's and Children's Hospital, North Adelaide, SA, Australia..-
dc.identifier.affiliationInfectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia..-
dc.identifier.affiliationDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia..-
dc.identifier.affiliationSydney Medical School, University of Sydney, NSW, Australia; Department of Infectious Diseases, Princess Margaret Hospital for Children, Subiaco, WA, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases and Infection Control, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Department of Infection and Immunity, Monash Children's Hospital, Clayton, VIC, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases & Microbiology, Children's Hospital at Westmead, Westmead, NSW, Australia..-
dc.identifier.affiliationDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia..-
dc.identifier.affiliationInfectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Murdoch Children's Research Institute, Parkville, VIC, Australia..-
dc.identifier.affiliationDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, University of New South Wales, NSW, Australia..-
dc.identifier.affiliationInfectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia..-
dc.identifier.affiliationDepartment of Pharmacy, Children's Hospital at Westmead, Westmead, NSW, Australia..-
dc.identifier.affiliationInfection Management and Prevention Service, Lady Cilento Children's Hospital, South Brisbane, QLD, Australia; School of Medicine, University of Queensland, Brisbane, QLD, Australia..-
dc.identifier.affiliationDepartment of Paediatrics, Royal Darwin Hospital, Darwin, NT, Australia..-
dc.identifier.affiliationDepartment of Infectious Diseases & Microbiology, Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, University of Sydney, Sydney, NSW, Australia..-
dc.identifier.affiliationInfectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. Electronic address: penelope.bryant@rch.org.au..-
dc.identifier.pubmedurihttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/27321363-
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