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Title: | Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever. |
Authors: | Wyber, Rosemary Boyd, Ben J Colquhoun, Samantha Currie BJ Engel, Mark Kado, Joseph Karthikeyan, Ganesan Sullivan, Mark Saxena, Anita Sheel, Meru Steer, Andrew Mucumbitsi, Joseph Zühlke, Liesl Carapetis, Jonathan |
Citation: | Drug delivery and translational research 2016; 6(5): 572-8 |
Abstract: | Rheumatic fever is caused by an abnormal immune reaction to group A streptococcal infection. Secondary prophylaxis with antibiotics is recommended for people after their initial episode of rheumatic fever to prevent recurrent group A streptococcal infections, recurrences of rheumatic fever and progression to rheumatic heart disease. This secondary prophylaxis must be maintained for at least a decade after the last episode of rheumatic fever. Benzathine penicillin G is the first line antibiotic for secondary prophylaxis, delivered intramuscularly every 2 to 4 weeks. However, adherence to recommended secondary prophylaxis regimens is a global challenge. This paper outlines a consultation with global experts in rheumatic heart disease on the characteristics of benzathine penicillin G formulations which could be changed to improve adherence with secondary prophylaxis. Characteristics included dose interval, pain, administration mechanism, cold chain independence and cost. A sample target product profile for reformulated benzathine penicillin G is presented. |
Click to open PubMed article: | https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//27465618 |
Journal title: | Drug delivery and translational research |
Publication Date: | 2016 |
Type: | Journal Article Research Support, Non-U.S. Gov't |
URI: | https://hdl.handle.net/10137/5336 |
DOI: | 10.1007/s13346-016-0313-z |
Appears in Collections: | (a) NT Health Research Collection |
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