Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5288
Email LibraryRMU.DOH@nt.gov.au to ask for this document in a different format
Title: Global and regional dissemination and evolution of Burkholderia pseudomallei.
Authors: Chewapreecha, Claire
Holden, Matthew T G
Vehkala, Minna
Välimäki, Niko
Yang, Zhirong
Harris, Simon R
Mather, Alison E
Tuanyok, Apichai
De Smet, Birgit
Le Hello, Simon
Bizet, Chantal
Mayo, Mark
Wuthiekanun, Vanaporn
Limmathurotsakul, Direk
Phetsouvanh, Rattanaphone
Spratt, Brian G
Corander, Jukka
Keim, Paul
Dougan, Gordon
Dance, David A B
Currie, Bart J
Parkhill, Julian
Peacock, Sharon J
Citation: Nature microbiology 2017-01-23; 2: 16263
Abstract: The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
Click to open PubMed article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/28112723
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/28112723
Journal title: Nature microbiology
Publication Date: 2017-01-23
Type: Journal Article
URI: https://hdl.handle.net/10137/5288
DOI: 10.1038/nmicrobiol.2016.263
metadata.dc.identifier.orcid: http://orcid.org/0000-0002-4958-2166
http://orcid.org/0000-0003-1512-6194
http://orcid.org/0000-0001-9189-7244
http://orcid.org/0000-0002-7069-5958
Appears in Collections:(a) NT Health Research Collection

Files in This Item:
There are no files associated with this item.


Items in ePublications are protected by copyright, with all rights reserved, unless otherwise indicated.