Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5263
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dc.contributor.authorMarr Ien
dc.contributor.authorDavies Jen
dc.contributor.authorBaird RWen
dc.date2017en
dc.date.accessioned2018-05-15T23:00:34Zen
dc.date.available2018-05-15T23:00:34Zen
dc.date.issued2017-05en
dc.identifier.citationInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017-05; 58: 90-95en
dc.identifier.urihttps://hdl.handle.net/10137/5263en
dc.description.abstractTo establish the relationship between hepatitis B virus (HBV) and human T-cell lymphotropic virus type 1 (HTLV-1) serological markers in the Northern Territory, Australia. A retrospective serological study of patients presenting to public healthcare facilities in the Northern Territory between 2008 and 2015 was performed in order to determine the presence and relationships of serological markers of HBV and HTLV-1. Seven hundred and forty individual patients were found to be serologically positive for HTLV-1 in the Northern Territory over the 8-year period. Hepatitis B results were available for 521 of these patients. Hepatitis B surface antigen (HBsAg) positivity was demonstrated in 15.9% (83/521) of this cohort, which was significantly different to the HTLV-1-negative group (3.7%, 125/3354) (p<0.001). Excluding individuals with isolated hepatitis B surface antibody (anti-HBs), those in the HTLV-1-positive group had a higher HBV exposure history (67.5%, 352/521) when compared to HTLV-1-negative individuals (37.8%, 1259/3354) (p<0.001). HTLV-1-positive individuals had a lower prevalence of HBV combined anti-HBs and hepatitis B core antibody (anti-HBc) positive markers compared to those who were HTLV-1-negative (56.3% (198/352) versus 73.8% (937/1269), respectively; p<0.001). A significantly higher prevalence rate of HBV was found in HTLV-1-positive individuals from the Northern Territory. When considering the higher exposure to HBV in HTLV-1-positive individuals, the clearance of HBV appears lower than in those individuals testing HTLV-1-negative. A lower prevalence of clearance in HTVL-1-positive individuals than in HTLV-1-negative individuals, as signified by formation of HBVcAb and HBVsAb in HTVL-1 positive individual's may equate to higher prevalence of ongoing coinfection.en
dc.language.isoengen
dc.subjectAustraliaen
dc.subjectCo-infectionen
dc.subjectHTLV-1en
dc.subjectHepatitis B virusen
dc.subjectNorthern Territoryen
dc.titleHepatitis B virus and human T-cell lymphotropic virus type 1 co-infection in the Northern Territory, Australia.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseasesen
dc.identifier.doi10.1016/j.ijid.2017.03.010en
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//28315754en
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshBiomarkersen
dc.subject.meshCoinfectionen
dc.subject.meshDNA, Viralen
dc.subject.meshFemaleen
dc.subject.meshHTLV-I Infectionsen
dc.subject.meshHepatitis Ben
dc.subject.meshHepatitis B Antibodiesen
dc.subject.meshHepatitis B Surface Antigensen
dc.subject.meshHepatitis B virusen
dc.subject.meshHuman T-lymphotropic virus 1en
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNorthern Territoryen
dc.subject.meshPrevalenceen
dc.subject.meshRetrospective Studiesen
dc.subject.meshSerologic Testsen
dc.identifier.affiliationInfectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Territory Pathology, Royal Darwin Hospital, Darwin, Northern Territory, Australia. Electronic address: Ian_Marr@gmx.com..en
dc.identifier.affiliationInfectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Menzies School of Health Research, Darwin, Northern Territory, Australia..en
dc.identifier.affiliationTerritory Pathology, Royal Darwin Hospital, Darwin, Northern Territory, Australia..en
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