Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/5196
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dc.contributor.authorCleland Gen
dc.contributor.authorLeung Cen
dc.contributor.authorWan Sai Cheong Jen
dc.contributor.authorFrancis JRen
dc.contributor.authorHeney Cen
dc.contributor.authorNourse Cen
dc.date2017en
dc.date.accessioned2018-05-15T23:00:29Zen
dc.date.available2018-05-15T23:00:29Zen
dc.date.issued2018-01en
dc.identifier.citationJournal of paediatrics and child health 2018-01; 54(1): 36-41en
dc.identifier.urihttps://hdl.handle.net/10137/5196en
dc.description.abstractHaemophilus influenzae continues to cause invasive disease in children despite widespread Hib immunisation. The significance of non-B serotypes continues to be investigated, with evidence of increased invasive non-typeable H. influenzae (NTHi) world-wide. The aim of this study was to examine the current epidemiological and clinical features of invasive H. influenzae disease in children in Queensland, Australia. A retrospective review was performed of all cases of invasive H. influenzae disease in children <18 years of age in Queensland between January 2002 and December 2011. Cases were identified from pathology records and data requested from treating hospitals. Laboratory data were obtained for 144 cases and clinical/demographic data for 123 cases. The majority (72%) of cases were children <5 years of age. Annual incidence rate for all children <5 years was 7.4/100 000, and for Aboriginal and Torres Strait Islander children <5 years was 10.2/100 000. Serotype was reported for 132 isolates, 69 NTHi and 63 encapsulated strains. The most common clinical diagnoses were pneumonia, meningitis and bacteraemia without clinical focus. Of the patients, 5 patients died, and 12 had significant morbidity at hospital discharge. While rates of invasive H. influenzae disease have decreased dramatically following the introduction of Hib vaccination, H. influenzae remains a cause of significant morbidity and mortality, and Aboriginal and Torres Strait Islander children remain particularly vulnerable.en
dc.language.isoengen
dc.subjectHaemophilus influenzae infectionsen
dc.subjectQueenslanden
dc.subjectimmunisationen
dc.subjectpaediatricen
dc.titlePaediatric invasive Haemophilus influenzae in Queensland, Australia, 2002-2011: Young Indigenous children remain at highest risk.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of paediatrics and child healthen
dc.identifier.doi10.1111/jpc.13662en
dc.identifier.pubmedidhttps://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed//28871608en
dc.identifier.affiliationDepartment of Paediatrics, Western Australian Country Health Service, Kimberley Region, Western Australia, Australia.. University of Western Australia, Perth, Western Australia, Australia..en
dc.identifier.affiliationInfection Management and Prevention Service, Lady Cilento Children's Hospital, Queensland, Australia.. University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationUniversity of Queensland, Brisbane, Queensland, Australia.. Pathology Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationDepartment of Paediatrics, Royal Darwin Hospital, Australia.. Northern Territory Medical Program, Flinders University, Australia.. Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia..en
dc.identifier.affiliationPathology Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationInfection Management and Prevention Service, Lady Cilento Children's Hospital, Queensland, Australia.. University of Queensland, Brisbane, Queensland, Australia..en
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