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Title: TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol.
Authors: Chow, Clara K
Thiagalingam, Aravinda
Santo, Karla
Kok, Cindy
Thakkar, Jay
Stepien, Sandrine
Billot, Laurent
Jan, Stephen
Joshi, Rohina
Hillis, Graham S
Brieger, David
Chew, Derek P
Rådholm, Karin
Atherton, John J
Bhindi, Ravinay
Collins, Nicholas
Coverdale, Steven
Hamilton-Craig, Christian
Kangaharan, Nadarajah
Maiorana, Andrew
McGrady, Michelle
Shetty, Pratap
Thompson, Peter
Rogers, Anthony
Redfern, Julie
Citation: BMJ open 2018; 8(1): e019463
Abstract: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS). A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. The intervention group will receive multiple weekly text messages that provide information, motivation, support to adhere to medications, quit smoking (if relevant) and recommendations for healthy diet and exercise. The primary endpoint is the percentage of patients who are adherent to cardioprotective medications and the key secondary outcomes are mean systolic blood pressure (BP) and low-density lipoprotein cholesterol. Secondary outcomes will also include total cholesterol, mean diastolic BP, the percentage of participants who are adherent to each cardioprotective medication class, the percentage of participants who achieve target levels of CV risk factors, major vascular events, hospital readmissions and all-cause mortality. The study will be augmented by formal economic and process evaluations to assess acceptability, utility and cost-effectiveness. The study will provide multicentre randomised trial evidence of the effects of a text message-based programme on cardioprotective medication adherence and levels of CV risk factors. Primary ethics approval was received from Western Sydney Local Health District Human Research Ethics Committee (HREC2012/12/4.1 (3648) AU RED HREC/13/WMEAD/15). Results will be disseminated via peer-reviewed publications and presentations at international conferences. ACTRN12613000793718; Pre-results.
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Journal title: BMJ open
Publication Date: 2018
Type: Journal Article
DOI: 10.1136/bmjopen-2017-019463
Orcid: 0000-0003-4693-0038
Appears in Collections:(a) NT Health Research Collection

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