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Title: Molecular phylogeny of Edge Hill virus supports its position in the yellow fever group and identifies a new genetic variant
Authors: Macdonald J
Poidinger M
Mackenzie JS
Russell RC
Doggett SL
Broom AK
Phillips DA
Potamski J
Gard G
Whelan PI
Weir R
Young PR
Gendle D
Maher S
Barnard RT
Hall RA
Series/Report no.: Evolutionary Bioinformatics
Vol. 6:91-96
Publisher: Libertas Academica Ltd
Abstract: Edge Hill virus (EHV) is a mosquito-borne flavivirus isolated throughout Australia during mosquito surveillance programs. While not posing an immediate threat to the human population, EHV is a taxonomically interesting flavivirus since it remains the only member of the yellow fever virus (YFV) sub-group to be detected within Australia. Here we present both an antigenic and genetic investigation of collected isolates, and confirm taxonomic classification of the virus within the YFV-group. Isolates were not clustered based on geographical origin or time of isolation, suggesting that minimal genetic evolution of EHV has occurred over geographic distance or time within the EHV cluster. However, two isolates showed significant differences in antigenic reactivity patterns, and had a much larger divergence from the EHV prototype (19% nucleotide and 6% amino acid divergence), indicating a distinct subtype or variant within the EHV subgroup.
Publication Date: 2010-06-15
ISSN: 1176-9343
Type: Journal Article
Appears in Collections:(b) NT General Collection

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